Naloxone and Zosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naloxone (naloxone hydrochloride) and Zosyn (piperacillin sodium; tazobactam sodium). Common drug interactions include pleural effusion among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Naloxone and Zosyn. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Naloxone?

Naloxone has active ingredients of naloxone hydrochloride. eHealthMe is studying from 6,425 Naloxone users. Check the latest studies of Naloxone.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

On Jul, 31, 2026

50 people who take Naloxone and Zosyn together, and have interactions are studied.

What are the common drug interactions of Naloxone and Zosyn, by gender? *:

female:

Pleural effusion (water on the lungs)
Respiratory failure (inadequate gas exchange by the respiratory system)
Abulia (lack of will or initiative)
Blindness cortical
Blood creatinine increased
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Capillary leak syndrome (capillary leaks plasma)
Death
Dehydration (dryness resulting from the removal of water)
Encephalitis (inflammation of the brain)

male:

Renal failure (kidney dysfunction)
Chronic kidney disease
Anaemia (lack of blood)
Bladder dilatation
Blood magnesium decreased
Blood potassium decreased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Coagulopathy (blood's ability to clot is impaired)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)

What are the common drug interactions of Naloxone and Zosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abulia (lack of will or initiative)
Blindness cortical
Dehydration (dryness resulting from the removal of water)
Encephalitis (inflammation of the brain)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Haematuria (presence of blood in urine)
Muscular weakness (muscle weakness)
Myositis (inflammation of the muscles)
Pain in extremity
Pancreatitis acute (sudden inflammation of pancreas)

20-29:

Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Sepsis (a severe blood infection that can lead to organ failure and death)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Anxiety
Groin infection (infection in groin)
Soft tissue infection
Abdominal pain
Anal abscess
Blood pressure decreased
Chest pain

30-39:

Chronic kidney disease
Renal failure (kidney dysfunction)
Transaminases increased
Headache (pain in head)
Renal injury (kidney injury)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

40-49:

Enterocutaneous fistula
Capillary leak syndrome (capillary leaks plasma)
Mucosal haemorrhage (bleeding from mucous membrane)
Palmar-plantar erythrodysaesthesia syndrome (hand-foot syndrome)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Pleural effusion (water on the lungs)
Pulseless electrical activity
Respiratory failure (inadequate gas exchange by the respiratory system)
Staphylococcal sepsis (blood infection by an infection with staphylococcus bacteria)

50-59:

Alanine aminotransferase increased
Aspartate aminotransferase increased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood albumin decreased
Blood bilirubin increased
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Cough
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Death
Disease progression

60+:

Hypotension (abnormally low blood pressure)
Respiratory failure (inadequate gas exchange by the respiratory system)
Dyspnoea (difficult or laboured respiration)
Fluid overload (too much fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Multi-organ failure (multisystem organ failure)
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 9 people, 18.00%
Pain: 7 people, 14.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 10.00%
Muscle Spasms (muscle contraction): 4 people, 8.00%
Insomnia (sleeplessness): 4 people, 8.00%
High Blood Pressure: 4 people, 8.00%
Fever: 4 people, 8.00%
Depression: 4 people, 8.00%
Type 2 Diabetes: 3 people, 6.00%
Pleural Effusion (water on the lungs): 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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