Naprosyn and Augmentin '125' drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naprosyn (naproxen) and Augmentin '125' (amoxicillin; clavulanate potassium). Common drug interactions include depression among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Naprosyn and Augmentin '125'. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

What is Augmentin '125'?

Augmentin '125' has active ingredients of amoxicillin; clavulanate potassium. It is often used in sinusitis. eHealthMe is studying from 10,452 Augmentin '125' users. Check the latest studies of Augmentin '125'.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

57 people who take Naprosyn and Augmentin '125' together, and have interactions are studied.

Naprosyn and Augmentin '125' drug interactions.

What are the common drug interactions of Naprosyn and Augmentin '125', by gender? *:

female:

Depression
Arthralgia (joint pain)
Colonic polyp (extra part of colon tissue grow in intestine)
Diarrhoea
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Osteonecrosis of jaw (death of bone of jaw)
Weight decreased
Decreased appetite
Haemorrhoids (a swollen vein or group of veins in the region of the anus)

male:

Anxiety
Pneumonia
Hepatic cyst
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Nausea (feeling of having an urge to vomit)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Atelectasis (partial or complete collapse of the lung)
Dizziness
Malaise (a feeling of general discomfort or uneasiness)
Neuropathy peripheral (surface nerve damage)

What are the common drug interactions of Naprosyn and Augmentin '125', by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Injury
Anxiety
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Emotional distress
General physical health deterioration (weak health status)
Pulmonary embolism (blockage of the main artery of the lung)
Chest pain
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Dyspnoea (difficult or laboured respiration)

30-39:

n/a

40-49:

Chest pain
Blood cholesterol increased
Constipation
Abdominal pain
Anxiety
Decreased interest
Excoriation (to tear or wear off the skin of)
Fatigue (feeling of tiredness)
General physical health deterioration (weak health status)
Groin pain

50-59:

Dyspnoea (difficult or laboured respiration)
Pyrexia (fever)
Anaemia (lack of blood)
Arthralgia (joint pain)
Decreased appetite
Neuropathy peripheral (surface nerve damage)
Lobar pneumonia (a form of pneumonia that affects a large and continuous area of the lobe of a lung)
Malaise (a feeling of general discomfort or uneasiness)
Muscle spasms (muscle contraction)
Osteomyelitis (infection of bone)

60+:

Pneumonia
Anxiety
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Death
Depression
Device related infection
Disability
Gastritis (inflammation of stomach)
Hyperkalaemia (damage to or disease of the kidney)
Injury

What are the existing conditions these people have? *

Menopause (end of monthly cycles in women): 10 people, 17.54%
Anaemia (lack of blood): 10 people, 17.54%
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 9 people, 15.79%
Osteomyelitis (infection of bone): 9 people, 15.79%
Osteolysis (dissolution of bone): 7 people, 12.28%
Nausea (feeling of having an urge to vomit): 5 people, 8.77%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Naprosyn and Augmentin '125'?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously