Naprosyn and Bextra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naprosyn (naproxen) and Bextra (valdecoxib). Common drug interactions include glossitis among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Naprosyn and Bextra. It is created by eHealthMe based on reports of 65 people who take the same drugs from the FDA, and is updated regularly.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

What is Bextra?

Bextra has active ingredients of valdecoxib. It is often used in pain. eHealthMe is studying from 20,994 Bextra users. Check the latest studies of Bextra.

On Jul, 18, 2026

65 people who take Naprosyn and Bextra together, and have interactions are studied.

What are the common drug interactions of Naprosyn and Bextra, by gender? *:

female:

Glossitis (infection of tongue with soreness)
Groin pain
Haemolytic anaemia (anaemia due to haemolysis)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hand fracture
Hepatic cyst
Hip fracture
Hyperkeratosis (thickening of the outer layer of the skin)
Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)
Hypomania (a mild form of mania, marked by elation and hyperactivity)

male:

Abdominal pain
Angina pectoris (chest pain due to ischemia of the heart muscle)
Malignant melanoma (skin cancer rises from melancytes)
Pneumonia
Pruritus (severe itching of the skin)
Tinea cruris (an infection of the groin caused by a fungus)
Cardiac disorder
Cardiomegaly (increased size of heart than normal)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Death

What are the common drug interactions of Naprosyn and Bextra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Fall
Hysterectomy
Pancreatitis (inflammation of pancreas)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Visual acuity reduced (reduced clearness of vision)

30-39:

Dizziness
Diarrhoea
Dysmenorrhoea (painful menstruation)
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Palpitations (feelings or sensations that your heart is pounding or racing)
Vomiting

40-49:

Abdominal pain
Death
Alanine aminotransferase increased
Aspartate aminotransferase increased
Back injury
Blood alkaline phosphatase increased
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Dyspepsia (indigestion)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

50-59:

Cardiac failure congestive
Chest wall mass
Chondromalacia (anterior knee pain due to irritation of the cartilage on the under surface of the kneecap)
Decreased appetite
Deformity (disfigurement)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dry mouth
Dyspepsia (indigestion)
Early satiety (feeling full before completing a normal sized meal)
Emotional distress

60+:

Asthenia (weakness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Drug hypersensitivity
Headache (pain in head)
Heart rate irregular
Hypertension (high blood pressure)
Oedema peripheral (superficial swelling)
Pneumonia
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Back Pain: 10 people, 15.38%
Osteoporosis (bones weak and more likely to break): 8 people, 12.31%
Breast Cancer: 8 people, 12.31%
Multiple Myeloma (cancer of the plasma cells): 4 people, 6.15%
Metastases To Bone (cancer spreads to bone): 4 people, 6.15%
Joint Pain: 4 people, 6.15%
Bipolar Disorder (mood disorder): 4 people, 6.15%

* Approximation only. Some reports may have incomplete information.

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