Naprosyn and Phenytoin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naprosyn (naproxen) and Phenytoin (phenytoin). Common drug interactions include drug intolerance among females and adverse event among males.

The phase IV clinical study analyzes what interactions people have when they take Naprosyn and Phenytoin. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

What is Phenytoin?

Phenytoin has active ingredients of phenytoin. It is often used in epilepsy. eHealthMe is studying from 15,753 Phenytoin users. Check the latest studies of Phenytoin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

15 people who take Naprosyn and Phenytoin together, and have interactions are studied.

Naprosyn and Phenytoin drug interactions.

What are the common drug interactions of Naprosyn and Phenytoin, by gender? *:

female:

Drug intolerance (drug sensitivity)
Hyperaesthesia
Hyperhidrosis (abnormally increased sweating)
Hypokinesia (decreased bodily movement)
Hypotonia (low muscle tone)
Joint contracture (a permanent shortening of a muscle or joint)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Muscular weakness (muscle weakness)
Peripheral coldness
Skin atrophy (wasting of skin)

male:

Adverse event
Disseminated tuberculosis
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Psychotic disorder

What are the common drug interactions of Naprosyn and Phenytoin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Head injury
Headache (pain in head)
Hepatic steatosis (fatty liver disease)
Infectious mononucleosis (infection usually caused by the epstein-barr virus)
Infertility
Injury
Insomnia (sleeplessness)
Loss of consciousness
Lymphadenitis (inflammation or enlargement of a lymph node)
Mastoptosis

30-39:

n/a

40-49:

Drug hypersensitivity
Brain mass
Brain neoplasm (tumour of brain)
Disseminated tuberculosis
Haemangioma (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)
Haemangiopericytoma (soft tissue cancer that originates in the pericytes in the walls of capillaries)
Headache (pain in head)
Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
Psychotic disorder

50-59:

Allodynia (a condition in which pain is caused by a stimulus that does not normally elicit pain)
Diarrhoea
Drug intolerance (drug sensitivity)
Hyperaesthesia
Hyperhidrosis (abnormally increased sweating)
Hypokinesia (decreased bodily movement)
Hypotonia (low muscle tone)
Joint contracture (a permanent shortening of a muscle or joint)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Muscular weakness (muscle weakness)

60+:

Fatigue (feeling of tiredness)
Acute respiratory failure
Hypophagia (reduced food intake)
Lethargy (tiredness)
Leukocytosis (increased white blood cells)
Nausea (feeling of having an urge to vomit)
Pneumonia
Renal failure acute (rapid kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Somnolence (a state of near-sleep, a strong desire for sleep)

What are the existing conditions these people have? *

Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 3 people, 20.00%
Sleep Disorder: 2 people, 13.33%
Skin Disorder (skin disease): 2 people, 13.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 13.33%
Cancer Pain: 2 people, 13.33%
Small Cell Lung Cancer Stage Unspecified (lung cancer in unknown stage): 1 person, 6.67%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 1 person, 6.67%
Gastric Disorder (disease of stomach): 1 person, 6.67%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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