Naprosyn and Piroxicam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naprosyn (naproxen) and Piroxicam (piroxicam). Common drug interactions include pericardial effusion among females and ankylosing spondylitis among males.

The phase IV clinical study analyzes what interactions people have when they take Naprosyn and Piroxicam. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

What is Piroxicam?

Piroxicam has active ingredients of piroxicam. It is often used in arthritis. eHealthMe is studying from 8,582 Piroxicam users. Check the latest studies of Piroxicam.

On Jul, 13, 2026

38 people who take Naprosyn and Piroxicam together, and have interactions are studied.

Naprosyn and Piroxicam drug interactions.

What are the common drug interactions of Naprosyn and Piroxicam, by gender? *:

female:

Pericardial effusion (fluid around the heart)
Tooth disorder (tooth disease)
Weight decreased
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Emotional distress
Foot fracture
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
General physical health deterioration (weak health status)
Haemorrhagic stroke (stroke caused by the rupture of a blood vessel in the brain)
Hypercholesterolaemia (high levels of cholesterol in the blood)

male:

Ankylosing spondylitis (type of arthritis affecting the spine)
Drug ineffective
Arthralgia (joint pain)
Bone disorder
Cardiac disorder
Cellulitis (infection under the skin)
Chest pain
Completed suicide (act of taking one's own life)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Cough

What are the common drug interactions of Naprosyn and Piroxicam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cavernous sinus thrombosis (formation of a blood clot in brain)
Diplopia (double vision)
Ophthalmoplegia (a paralysis or weakness of one or more of the muscles that control eye movement)
Vith nerve paralysis
Abdominal pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Gradenigo's syndrome (complication of middle ear infection)
Headache (pain in head)
Herpes zoster oticus (viral infection of the inner, middle, and external ear caused by varicella-zoster virus (vzv))
Hypotension (abnormally low blood pressure)

20-29:

Anxiety
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Emotional distress
General physical health deterioration (weak health status)
Haemorrhagic stroke (stroke caused by the rupture of a blood vessel in the brain)
Injury
Skull fractured base
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Subdural haemorrhage (bleeding between the skull and the surface of the brain)

30-39:

Angioedema (rapid swelling of the dermis)
Face oedema (swelling of face)
Oral pruritus (itching in mouth)
Tongue oedema (swelling of tongue)
Urticaria (rash of round, red welts on the skin that itch intensely)

40-49:

Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Joint contracture (a permanent shortening of a muscle or joint)
Loose tooth
Mood disorder due to a general medical condition
Multiple fractures
Myalgia (muscle pain)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nasopharyngitis (inflammation of the nasopharynx)
Nausea (feeling of having an urge to vomit)
Nephrolithiasis (calculi in the kidneys)

50-59:

Drug ineffective
Ankylosing spondylitis (type of arthritis affecting the spine)
Arthralgia (joint pain)
Chest pain
Completed suicide (act of taking one's own life)
Discomfort
Drug abuse
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Fatigue (feeling of tiredness)
Infection

60+:

Drug hypersensitivity
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Hypertension (high blood pressure)
Injury
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Arthralgia (joint pain)
Blood cholesterol increased
Cardiac failure congestive
Congestive (dilated) cardiomyopathy (weakening of dilated heart muscle)
Ejection fraction decreased (systolic heart failure)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 13.16%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 10.53%
Depression: 4 people, 10.53%
Back Pain: 4 people, 10.53%
Ankylosing Spondylitis (type of arthritis affecting the spine): 4 people, 10.53%
Spondyloarthropathy (any joint disease of the vertebral column): 3 people, 7.89%
Ovarian Cysts (fluid filled sacs of the ovary): 3 people, 7.89%
Oedema (fluid collection in tissue): 3 people, 7.89%
Juvenile Arthritis (arthritis-related condition that develops in children or teenagers): 3 people, 7.89%
Infection: 3 people, 7.89%

* Approximation only. Some reports may have incomplete information.

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