Naprosyn and Propulsid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naprosyn (naproxen) and Propulsid (cisapride monohydrate). Common drug interactions include cardiac failure congestive among females and abdominal pain upper among males.

The phase IV clinical study analyzes what interactions people have when they take Naprosyn and Propulsid. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

What is Propulsid?

Propulsid has active ingredients of cisapride monohydrate. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 8,130 Propulsid users. Check the latest studies of Propulsid.

On Jul, 10, 2026

32 people who take Naprosyn and Propulsid together, and have interactions are studied.

Naprosyn and Propulsid drug interactions.

What are the common drug interactions of Naprosyn and Propulsid, by gender? *:

female:

Cardiac failure congestive
Cataract (clouding of the lens inside the eye)
Cough
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Hypertension (high blood pressure)
Hypoxia (low oxygen in tissues)
Injury
Insomnia (sleeplessness)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)

male:

Abdominal pain upper
Cholecystitis (infection of gallbladder)
International normalised ratio increased
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Post-operative pain
Renal failure (kidney dysfunction)
Tremor (trembling or shaking movements in one or more parts of your body)
Abdominal abscess (collection of pus in abdomen)
Abscess (pus)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

What are the common drug interactions of Naprosyn and Propulsid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chest pain
Dyspnoea (difficult or laboured respiration)
Aortic valve incompetence
Mitral valve incompetence (inefficient heart valve)
Oedema lower limb (fluid collection in tissue of lower leg)
Tricuspid valve incompetence (inefficient heart valve)
Abdominal pain
Arthralgia (joint pain)
Cardiac disorder
Cardiovascular disorder (heart diseases)

40-49:

Asthma
Dyspnoea (difficult or laboured respiration)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Productive cough
Abdominal pain
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Antiphospholipid syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss)
Anxiety
Arteriospasm coronary (spasm of the large- or medium-sized coronary arteries)

50-59:

Nausea (feeling of having an urge to vomit)
Nervousness
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Tremor (trembling or shaking movements in one or more parts of your body)
Vomiting
Abdominal pain upper
Cholecystitis (infection of gallbladder)
Constipation
Headache (pain in head)
Insomnia (sleeplessness)

60+:

Chest pain
Dyspnoea (difficult or laboured respiration)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Blood creatinine increased
Blood potassium increased
Blood urea increased
Bradycardia (abnormally slow heart action)
Cardiomegaly (increased size of heart than normal)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Dehydration (dryness resulting from the removal of water)

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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