Naprosyn and Savella drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naprosyn (naproxen) and Savella (milnacipran hydrochloride). Common drug interactions include psoriasis among females and encephalopathy among males.

The phase IV clinical study analyzes what interactions people have when they take Naprosyn and Savella. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

On Aug, 01, 2026

24 people who take Naprosyn and Savella together, and have interactions are studied.

What are the common drug interactions of Naprosyn and Savella, by gender? *:

female:

Psoriasis (immune-mediated disease that affects the skin)
Sinusitis (inflammation of sinus)
Sjogren's syndrome (a disease that causes dryness in the mouth and eyes)
Snoring
Amylase increased
Arthralgia (joint pain)
Burning sensation
Disability
Hypotension (abnormally low blood pressure)
Stress

male:

Encephalopathy (functioning of the brain is affected by some agent or condition)
Sleep disorder

What are the common drug interactions of Naprosyn and Savella, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Nausea (feeling of having an urge to vomit)
Vomiting

40-49:

Dehydration (dryness resulting from the removal of water)
Drug ineffective
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Inflammation
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Acute myocardial infarction (acute heart attack)
Anxiety
Chest pain
Crying

50-59:

Amylase increased
Lipase increased
Mental impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Sleep disorder

60+:

Drug hypersensitivity

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 12 people, 50.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 50.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 8.33%
Intervertebral Disc Protrusion (spinal disc protrusion): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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