Naprosyn and Sinemet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naprosyn (naproxen) and Sinemet (carbidopa; levodopa). Common drug interactions include oedema peripheral among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Naprosyn and Sinemet. It is created by eHealthMe based on reports of 87 people who take the same drugs from the FDA, and is updated regularly.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

On Jul, 27, 2026

87 people who take Naprosyn and Sinemet together, and have interactions are studied.

What are the common drug interactions of Naprosyn and Sinemet, by gender? *:

female:

Oedema peripheral (superficial swelling)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Swelling
Vision blurred
Vomiting
Weight decreased
Bone disorder
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Fistula (an abnormal connection or passageway between two)

male:

Depression
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Rash erythematous (redness of the skin)
Pleural effusion (water on the lungs)
Pyrexia (fever)
Oedema peripheral (superficial swelling)
Sweating increased (excess sweating)
Tremor (trembling or shaking movements in one or more parts of your body)
Compulsions (performing an act persistently and repetitively)
Drug intolerance (drug sensitivity)

What are the common drug interactions of Naprosyn and Sinemet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Vomiting
Anxiety
Depression
Dyspnoea (difficult or laboured respiration)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Abdominal pain
Antiphospholipid syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss)

50-59:

Fall
Fatigue (feeling of tiredness)
Fistula (an abnormal connection or passageway between two)
Gait disturbance
Haematochezia (passage of stools containing blood)
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Joint sprain (an injury to joint surrounding flexible fibres)
Muscular weakness (muscle weakness)
Musculoskeletal chest pain (pain in chest muscle or nerve or bones)

60+:

Drug hypersensitivity
Pneumonia
Abdominal pain upper
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Arthralgia (joint pain)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Depressed level of consciousness
Duodenal ulcer
Dyskinesia (abnormality or impairment of voluntary movement)

What are the existing conditions these people have? *

High Blood Pressure: 18 people, 20.69%
Constipation: 13 people, 14.94%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 12 people, 13.79%
Metastases To Bone (cancer spreads to bone): 11 people, 12.64%
Breast Cancer: 11 people, 12.64%
Bone Pain: 11 people, 12.64%
Back Pain: 11 people, 12.64%
Restless Leg Syndrome (a powerful urge to move your legs): 8 people, 9.20%
Phobia Of Flying (fear of flying): 6 people, 6.90%
Stress And Anxiety: 5 people, 5.75%

* Approximation only. Some reports may have incomplete information.

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