Naprosyn and Sustiva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naprosyn (naproxen) and Sustiva (efavirenz). Common drug interactions include multiple fractures among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Naprosyn and Sustiva. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

What is Sustiva?

Sustiva has active ingredients of efavirenz. It is often used in hiv infection. eHealthMe is studying from 11,040 Sustiva users. Check the latest studies of Sustiva.

On Jul, 20, 2026

25 people who take Naprosyn and Sustiva together, and have interactions are studied.

What are the common drug interactions of Naprosyn and Sustiva, by gender? *:

female:

Multiple fractures
Muscle cramp (painful sensation caused by muscle contraction)
Nausea (feeling of having an urge to vomit)
Nephrolithiasis (calculi in the kidneys)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Oedema peripheral (superficial swelling)
Oropharyngeal plaque (hard deposit on oropharynx)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)

male:

Anxiety
Chronic kidney disease
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Anaemia (lack of blood)
Dysstasia (difficulty in standing)
Gait disturbance

What are the common drug interactions of Naprosyn and Sustiva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Lymphadenopathy (disease or enlargement of lymph nodes)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Pneumonitis aspiration (acute lung injury after the inhalation of regurgitated gastric contents)
Pulmonary haemorrhage (acute bleeding from the lung)
Thrombocytopenia (decrease of platelets in blood)
Weakness
Blood bicarbonate decreased
Haemoglobin decreased
Lymphoma (cancer that begins in immune system cells)

40-49:

Anxiety
Chronic kidney disease
Osteoporosis (bones weak and more likely to break)
Renal failure (kidney dysfunction)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone density decreased
Depression
Emotional distress
Foot fracture
Spinal fracture (fracture in one of vertebrae)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)
Acute myocardial infarction (acute heart attack)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Cardiac murmur (an heart sound in valve abnormality)
Dyspnoea (difficult or laboured respiration)
Emotional distress
Hepatic enzyme increased
Hydronephrosis (water inside the kidney)

60+:

Abdominal distension
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Foot fracture
Fracture
Anxiety
Bone density decreased
Chronic kidney disease
Dysstasia (difficulty in standing)
Gait disturbance
Emotional distress

What are the existing conditions these people have? *

Hiv Infection: 11 people, 44.00%
Sleep Disorder: 3 people, 12.00%
Inflammation: 3 people, 12.00%
High Blood Pressure: 3 people, 12.00%
High Blood Cholesterol: 3 people, 12.00%
Hepatitis C: 3 people, 12.00%
Hepatitis B: 3 people, 12.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 12.00%
Enlarged Prostate: 3 people, 12.00%
Depression: 3 people, 12.00%

* Approximation only. Some reports may have incomplete information.

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