Narcan and Duoneb drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Narcan (naloxone hydrochloride) and Duoneb (albuterol sulfate; ipratropium bromide). Common drug interactions include deep vein thrombosis among females and hepatic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Narcan and Duoneb. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

What is Duoneb?

Duoneb has active ingredients of albuterol sulfate; ipratropium bromide. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 8,093 Duoneb users. Check the latest studies of Duoneb.

On Jul, 16, 2026

56 people who take Narcan and Duoneb together, and have interactions are studied.

What are the common drug interactions of Narcan and Duoneb, by gender? *:

female:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Lumbar vertebral fracture
Muscle spasms (muscle contraction)
Neck pain
Productive cough
Pulmonary embolism (blockage of the main artery of the lung)
Rib fracture
Anaphylactic reaction (serious allergic reaction)
Blood albumin decreased
Blood alkaline phosphatase increased

male:

Hepatic fibrosis (scarring process that represents the liver's response to injury)
Hereditary angioedema (recurrent episodes of severe swelling)
Pain
Pneumonia
Adverse drug reaction
Alcohol abuse
Chest pain
Cough
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Headache (pain in head)

What are the common drug interactions of Narcan and Duoneb, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Alcohol abuse
Dyspnoea (difficult or laboured respiration)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Groin abscess (pus in groin)
Lung abscess (pus in lungs)
Renal failure (kidney dysfunction)
Urinary tract infection
Abscess (pus)
Abscess limb (limb infection)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

50-59:

Muscle spasms (muscle contraction)
Neck pain
Productive cough
Abdominal pain
Anaemia (lack of blood)
Anaphylactic reaction (serious allergic reaction)
Blood albumin decreased
Blood alkaline phosphatase increased
Cough
Diarrhoea

60+:

Urinary tract infection
Anaemia (lack of blood)
Pulmonary embolism (blockage of the main artery of the lung)
Small intestinal obstruction (blockage in small intestine)
Abdominal pain
Blood homocysteine increased
Cardiac arrest
Circulatory collapse
Death
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the existing conditions these people have? *

Pain: 10 people, 17.86%
Immune System Disorder: 9 people, 16.07%
Constipation: 8 people, 14.29%
Nausea (feeling of having an urge to vomit): 7 people, 12.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 12.50%
High Blood Pressure: 6 people, 10.71%
Cough: 5 people, 8.93%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 5 people, 8.93%
Wheezing (a high-pitched whistling sound made while you breath): 4 people, 7.14%
Depression: 4 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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