Narcan and Emla drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Narcan (naloxone hydrochloride) and Emla (lidocaine; prilocaine). Common drug interactions include body dysmorphic disorder among females and alcohol abuse among males.

The phase IV clinical study analyzes what interactions people have when they take Narcan and Emla. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

What is Emla?

Emla has active ingredients of lidocaine; prilocaine. eHealthMe is studying from 5,276 Emla users. Check the latest studies of Emla.

On Jul, 06, 2026

43 people who take Narcan and Emla together, and have interactions are studied.

What are the common drug interactions of Narcan and Emla, by gender? *:

female:

Body dysmorphic disorder (type of mental illness)
Breast cancer
Colitis (inflammation of colon)
Constipation
Cough
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea
Disease progression
Disturbance in attention

male:

Alcohol abuse
Cellulitis (infection under the skin)
Abscess limb (limb infection)
Anal abscess
Asthenia (weakness)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic kidney disease
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)

What are the common drug interactions of Narcan and Emla, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hypotension (abnormally low blood pressure)
Abdominal pain
Cellulitis (infection under the skin)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diarrhoea
Hyperchloraemia (an excess of chlorides in the blood)
Hypertransaminasaemia
Hypoalbuminaemia (levels of albumin in blood serum are abnormally low)
Hypoxia (low oxygen in tissues)
Pyrexia (fever)

20-29:

Anxiety disorder
Body dysmorphic disorder (type of mental illness)
Constipation
Cough
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Diarrhoea
Disturbance in attention
Dyspnoea (difficult or laboured respiration)

30-39:

n/a

40-49:

Rectal abscess (pus in rectum)
Renal failure (kidney dysfunction)
Tooth abscess (pus formation in tooth)
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
Cellulitis (infection under the skin)
Dyspnoea (difficult or laboured respiration)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Cellulitis gangrenous (localized inflammation of the soft or connective tissue with considerable mass of body tissue dies (necrosis))
Gangrene (body tissue dies)

50-59:

Acute respiratory failure
Anaemia (lack of blood)
Lymphocyte count decreased
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Thrombocytopenia (decrease of platelets in blood)
Upper gastrointestinal haemorrhage (upper gastrointestinal bleeding)
Abdominal discomfort
Abdominal pain
Arthralgia (joint pain)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)

60+:

Anxiety
Asthenia (weakness)
Lymphoma (cancer that begins in immune system cells)
Myelodysplastic syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged)
Neutropenia (an abnormally low number of neutrophils)
Pain in extremity
Pancreatitis (inflammation of pancreas)
Renal failure (kidney dysfunction)
Vena cava thrombosis (clotting of the blood in large vein carrying deoxygenated blood into the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)

What are the existing conditions these people have? *

Pain: 18 people, 41.86%
Nausea (feeling of having an urge to vomit): 9 people, 20.93%
Constipation: 9 people, 20.93%
Stress And Anxiety: 8 people, 18.60%
Insomnia (sleeplessness): 6 people, 13.95%
Depression: 6 people, 13.95%
Weight Decreased: 4 people, 9.30%
Type 2 Diabetes: 4 people, 9.30%
Hypotension (abnormally low blood pressure): 4 people, 9.30%
High Blood Pressure: 4 people, 9.30%

* Approximation only. Some reports may have incomplete information.

Do you take Narcan and Emla?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously