Narcan and Keppra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Narcan (naloxone hydrochloride) and Keppra (levetiracetam). Common drug interactions include encephalopathy among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Narcan and Keppra. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

What is Keppra?

Keppra has active ingredients of levetiracetam. It is often used in epilepsy. eHealthMe is studying from 73,504 Keppra users. Check the latest studies of Keppra.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

68 people who take Narcan and Keppra together, and have interactions are studied.

What are the common drug interactions of Narcan and Keppra, by gender? *:

female:

Encephalopathy (functioning of the brain is affected by some agent or condition)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nausea (feeling of having an urge to vomit)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Surgical failure
Tremor (trembling or shaking movements in one or more parts of your body)
Vision blurred
Visual impairment
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Contusion (a type of hematoma of tissue in which capillaries)

male:

Arthralgia (joint pain)
Rash
Pigmentation disorder (disturbances of human skin colour)
Purpura (purplish discoloration of the skin)
Rash macular (small, flat red spots)
Skin hyperpigmentation (disorders affect the colour of your skin)
Skin plaque (red, scaly patches to appear on the skin)
Skin ulcer haemorrhage (bleeding skin ulcer)
Mobility decreased (ability to move is reduced)
Pain in extremity

What are the common drug interactions of Narcan and Keppra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Blood creatinine increased
Blood lactic acid increased
Blood urea increased
Bone marrow failure
Bradycardia (abnormally slow heart action)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Cytokine storm (over-protective immune response that can actually be fatal)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

20-29:

Proctalgia (pain in the rectum)
Anaemia (lack of blood)
Anaphylactoid reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation)
B-cell type acute leukaemia (cancer of the white blood cells)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Candida sepsis (candida in blood stream)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Confusional state
Contusion (a type of hematoma of tissue in which capillaries)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)

30-39:

Arthralgia (joint pain)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Generalised oedema (swelling all over the body)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Pain
Petechiae (a small red or purple spot caused by bleeding into the skin)
Pigmentation disorder (disturbances of human skin colour)
Purpura (purplish discoloration of the skin)
Rash

40-49:

Fatigue (feeling of tiredness)
Hypersomnia (excessive daytime sleepiness (eds))
Arthralgia (joint pain)
Asthenia (weakness)
Back pain
Catheter site discharge
Cellulitis (infection under the skin)
Confusional state
Contusion (a type of hematoma of tissue in which capillaries)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

50-59:

Colitis (inflammation of colon)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dysphagia (a condition in which swallowing is difficult or painful)
Fall
Hyperhidrosis (abnormally increased sweating)
Hypoaesthesia (reduced sense of touch or sensation)
Limb discomfort (discomfort in leg)
Migraine (headache)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nasopharyngitis (inflammation of the nasopharynx)

60+:

Somnolence (a state of near-sleep, a strong desire for sleep)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Thrombosis (formation of a blood clot inside a blood vessel)
Wound infection
Abdominal hernia
Abdominal pain
Actinomycosis (infection that causes sores, or abscesses)
Activities of daily living impaired
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue)

What are the existing conditions these people have? *

Pain: 23 people, 33.82%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 13 people, 19.12%
Depression: 10 people, 14.71%
Nausea (feeling of having an urge to vomit): 10 people, 14.71%
Stress And Anxiety: 9 people, 13.24%
Nausea And Vomiting: 8 people, 11.76%
Migraine (headache): 7 people, 10.29%
Back Pain: 7 people, 10.29%
Constipation: 7 people, 10.29%
Nuclear Magnetic Resonance Imaging Brain: 7 people, 10.29%

* Approximation only. Some reports may have incomplete information.

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