Narcan and Prilosec otc drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Narcan (naloxone hydrochloride) and Prilosec otc (omeprazole magnesium). Common drug interactions include chronic kidney disease among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Narcan and Prilosec otc. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

What is Prilosec otc?

Prilosec otc has active ingredients of omeprazole magnesium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 38,394 Prilosec otc users. Check the latest studies of Prilosec otc.

On Jul, 23, 2026

43 people who take Narcan and Prilosec otc together, and have interactions are studied.

Narcan and Prilosec otc drug interactions.

What are the common drug interactions of Narcan and Prilosec Otc, by gender? *:

female:

Chronic kidney disease
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal injury (kidney injury)
Gastritis (inflammation of stomach)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Irritable bowel syndrome
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Proteinuria (presence of protein in the urine)

male:

Chronic kidney disease
Renal failure (kidney dysfunction)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypertension (high blood pressure)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Protein urine
Stress
Gastric cancer (stomach cancer)
Renal cyst (kidney cyst)

What are the common drug interactions of Narcan and Prilosec Otc, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Gastritis (inflammation of stomach)
Renal failure (kidney dysfunction)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal cyst (kidney cyst)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

50-59:

Nephrogenic anaemia (anaemia due to kidney disease)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal injury (kidney injury)
Irritable bowel syndrome
Proteinuria (presence of protein in the urine)
Gastric cancer (stomach cancer)
Chronic kidney disease
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Renal tubular necrosis (death of kidney tubules)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Death

What are the existing conditions these people have? *

Pain: 24 people, 55.81%
Infection: 12 people, 27.91%
High Blood Cholesterol: 9 people, 20.93%
Depression: 8 people, 18.60%
Neuralgia (pain in one or more nerves): 8 people, 18.60%
High Blood Pressure: 8 people, 18.60%
Indigestion: 7 people, 16.28%
Blood Pressure Abnormal: 7 people, 16.28%
Diabetes: 7 people, 16.28%
Muscle Spasms (muscle contraction): 7 people, 16.28%

* Approximation only. Some reports may have incomplete information.

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