Narcan and Ursodiol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Narcan (naloxone hydrochloride) and Ursodiol (ursodiol). Common drug interactions include nasal congestion among females and blood calcium decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Narcan and Ursodiol. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

What is Ursodiol?

Ursodiol has active ingredients of ursodiol. It is often used in primary biliary cirrhosis. eHealthMe is studying from 19,061 Ursodiol users. Check the latest studies of Ursodiol.

On Jul, 17, 2026

44 people who take Narcan and Ursodiol together, and have interactions are studied.

What are the common drug interactions of Narcan and Ursodiol, by gender? *:

female:

Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Neoplasm malignant (cancer tumour)
Asthma
Death
Pain
Urinary tract infection
Nausea (feeling of having an urge to vomit)
Uterine cancer
Escherichia infection (bacterial infection by escherichia coli)

male:

Blood calcium decreased
Blood sodium decreased
Hypoaesthesia (reduced sense of touch or sensation)
Hypoxia (low oxygen in tissues)
Intestinal obstruction
Multiple allergies (allergy to multiple agents)
Neoplasm malignant (cancer tumour)
Pancreatitis acute (sudden inflammation of pancreas)
Pericardial effusion (fluid around the heart)
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)

What are the common drug interactions of Narcan and Ursodiol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Infection
Rash
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chest pain
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Neoplasm malignant (cancer tumour)
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)

30-39:

Cystic fibrosis (disease of the secretary glands)
Febrile neutropenia (fever with reduced white blood cells)
Infection
Pancreatitis acute (sudden inflammation of pancreas)

40-49:

Blood calcium decreased
Blood sodium decreased
Blood urea increased
Death
Dysaesthesia (abnormal sensation)
Dyskinesia (abnormality or impairment of voluntary movement)
Enterococcus test positive
Hypoxia (low oxygen in tissues)
Intestinal obstruction
Migraine (headache)

50-59:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Bile output increased
Pain
Radiation injury (injuries are caused by radiation)

60+:

Death
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Nausea (feeling of having an urge to vomit)
Tremor (trembling or shaking movements in one or more parts of your body)
Anticonvulsant drug level decreased
Cardiac failure
Confusional state
Dizziness
Dysphemia (stammering or stuttering)
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 8 people, 18.18%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 9.09%
Pain: 3 people, 6.82%
Nausea And Vomiting: 3 people, 6.82%
Nausea (feeling of having an urge to vomit): 3 people, 6.82%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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