Narcan and Vioxx drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Narcan (naloxone hydrochloride) and Vioxx (rofecoxib). Common drug interactions include colon cancer among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Narcan and Vioxx. It is created by eHealthMe based on reports of 28 people who take the same drugs from the FDA, and is updated regularly.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

What is Vioxx?

Vioxx has active ingredients of rofecoxib. It is often used in arthritis. eHealthMe is studying from 110,130 Vioxx users. Check the latest studies of Vioxx.

On Jul, 10, 2026

28 people who take Narcan and Vioxx together, and have interactions are studied.

What are the common drug interactions of Narcan and Vioxx, by gender? *:

female:

Colon cancer
Confusional state
Deafness neurosensory
Dental caries
Dental fistula
Ear neoplasm (tour in ear)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Face oedema (swelling of face)
Fibroma (tumours that are composed of fibrous or connective tissue)
Gastritis (inflammation of stomach)

male:

Arthralgia (joint pain)
Cardiomegaly (increased size of heart than normal)
Coma (state of unconsciousness lasting more than six hours)
Dyspnoea (difficult or laboured respiration)
Nocturia (the need to get up in the night to urinate)
Somnolence (a state of near-sleep, a strong desire for sleep)
Vomiting
Wheezing (a high-pitched whistling sound made while you breath)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Diarrhoea

What are the common drug interactions of Narcan and Vioxx, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cardiomegaly (increased size of heart than normal)
Delirium (wild excitement)
Drug toxicity
Dyspepsia (indigestion)
Hypoaesthesia (reduced sense of touch or sensation)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Bone pain
Chest pain
Chronic obstructive airways disease
Coma (state of unconsciousness lasting more than six hours)

40-49:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

50-59:

Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Type 1 diabetes mellitus
Chronic kidney disease
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal disorder (kidney disease)
Renal failure (kidney dysfunction)
Renal tubular acidosis (medical condition that involves an accumulation of acid in the body due to a failure of the kidneys)

60+:

Abscess jaw (tooth abscess or root abscess)
Activities of daily living impaired
Bone disorder
Bruxism (habitual grinding of the teeth, typically during sleep)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cardiac disorder
Cardiac failure congestive
Carotid artery stenosis (narrowing of carotid artery)
Cataract (clouding of the lens inside the eye)
Charles bonnet syndrome (a condition that causes patients with visual loss to have complex visual hallucinations)

What are the existing conditions these people have? *

Pain: 17 people, 60.71%
Metastases To Bone (cancer spreads to bone): 12 people, 42.86%
Depression: 4 people, 14.29%
Stress And Anxiety: 4 people, 14.29%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 14.29%
Inflammation: 3 people, 10.71%
Infection: 3 people, 10.71%
High Blood Pressure: 3 people, 10.71%
Urination - Excessive Volume: 2 people, 7.14%
Age-Related Macular Degeneration: 2 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Narcan and Vioxx?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously