Narcan and Zosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Narcan (naloxone hydrochloride) and Zosyn (piperacillin sodium; tazobactam sodium). Common drug interactions include dysfunctional uterine bleeding among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Narcan and Zosyn. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

On Jul, 10, 2026

60 people who take Narcan and Zosyn together, and have interactions are studied.

What are the common drug interactions of Narcan and Zosyn, by gender? *:

female:

Dysfunctional uterine bleeding
Facial pain
Febrile neutropenia (fever with reduced white blood cells)
Fistula (an abnormal connection or passageway between two)
Gastrointestinal obstruction
Gingival erythema (redness of gums)
Gingival swelling (gums swelling)
Granuloma (a small area of inflammation due to tissue injury)
Hydronephrosis (water inside the kidney)
Hypoxia (low oxygen in tissues)

male:

Renal failure (kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Groin abscess (pus in groin)
Rectal abscess (pus in rectum)
Leukocytosis (increased white blood cells)
Perineal abscess
Abscess limb (limb infection)
Pyrexia (fever)
Scrotal abscess (pus in scrotum)
Scrotal erythema (redness of scrotum area)

What are the common drug interactions of Narcan and Zosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hypotension (abnormally low blood pressure)
Septic shock (shock due to blood infection)
Acute lymphocytic leukaemia recurrent (cancer in which the bone marrow makes too many lymphocytes-recurrent)
Aspergillosis (an infection caused by a fungus called aspergillus)
Blood creatinine increased
Blood lactic acid increased
Blood urea increased
Bone marrow failure
Bradycardia (abnormally slow heart action)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)

20-29:

Anxiety
Brain compression
Cerebellar infarction (impaired blood circulation to cerebellum)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Emotional distress
General physical health deterioration (weak health status)
Injury
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pain

30-39:

Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Renal failure (kidney dysfunction)
Acute left ventricular failure (heart attack)
Acute respiratory failure
Agitation (state of anxiety or nervous excitement)
Depression
Nephrogenic anaemia (anaemia due to kidney disease)

40-49:

Dyspnoea (difficult or laboured respiration)
Abdominal pain
Arthralgia (joint pain)
Benign neoplasm of thyroid gland (benign (non-cancerous) tumours of the thyroid gland)
Bone disorder
Colon neoplasm (cancer from uncontrolled cell growth in the colon or rectum)
Decreased interest
Defaecation urgency (a sudden compelling urge to defecate)
Depression
Dysfunctional uterine bleeding

50-59:

Abscess (pus)
Anal abscess
Groin abscess (pus in groin)
Perineal abscess
Rectal abscess (pus in rectum)
Dyspnoea (difficult or laboured respiration)
Hypotension (abnormally low blood pressure)
Scrotal abscess (pus in scrotum)
Scrotal erythema (redness of scrotum area)
Abdominal pain

60+:

Anaemia (lack of blood)
Asthenia (weakness)
Pleural effusion (water on the lungs)
Septic shock (shock due to blood infection)
Small intestinal obstruction (blockage in small intestine)
Back pain
Cellulitis (infection under the skin)
General physical health deterioration (weak health status)
Malaise (a feeling of general discomfort or uneasiness)
Pyrexia (fever)

What are the existing conditions these people have? *

Pain: 11 people, 18.33%
Weight Decreased: 9 people, 15.00%
Type 2 Diabetes: 9 people, 15.00%
Hypotension (abnormally low blood pressure): 9 people, 15.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 15.00%
High Blood Pressure: 8 people, 13.33%
Metastases To Bone (cancer spreads to bone): 7 people, 11.67%
Constipation: 7 people, 11.67%
Stress And Anxiety: 4 people, 6.67%
Multiple Myeloma (cancer of the plasma cells): 4 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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