Nicorette and Cephalexin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nicorette (nicotine polacrilex) and Cephalexin (cephalexin). Common drug interactions include hypertension among females and arthritis among males.

The phase IV clinical study analyzes what interactions people have when they take Nicorette and Cephalexin. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Nicorette?

Nicorette has active ingredients of nicotine polacrilex. It is often used in quit smoking. eHealthMe is studying from 18,484 Nicorette users. Check the latest studies of Nicorette.

What is Cephalexin?

Cephalexin has active ingredients of cephalexin. It is often used in infection. eHealthMe is studying from 30,580 Cephalexin users. Check the latest studies of Cephalexin.



On Jul, 18, 2026

17 people who take Nicorette and Cephalexin together, and have interactions are studied.

Nicorette and Cephalexin drug interactions.

What are the common drug interactions of Nicorette and Cephalexin, by gender? *:

female:

  1. Hypertension (high blood pressure)
  2. Hypoaesthesia (reduced sense of touch or sensation)
  3. Ill-defined disorder
  4. Insomnia (sleeplessness)
  5. Intervertebral disc degeneration (spinal disc degeneration)
  6. Intervertebral disc protrusion (spinal disc protrusion)
  7. Intestinal polyp (small growths in the bowel with the potential for further growth)
  8. Irritability
  9. Joint dislocation (a joint position is changed from normal position)
  10. Joint effusion (presence of extra fluid in joint covering)

male:

  1. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  2. Delusion (a false belief or opinion)
  3. Suicidal ideation
  4. Suicide attempt
  5. Adverse drug reaction
  6. Application site pain
  7. Application site paraesthesia (abnormal skin sensation of tingling, tickling, prickling, pricking, or burning felt at application site)
  8. Arthralgia (joint pain)
  9. Blood magnesium decreased
  10. Bone pain

What are the common drug interactions of Nicorette and Cephalexin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Maternal exposure during pregnancy (use of substance during pregnancy)

30-39:

  1. Anxiety
  2. Circulatory collapse
  3. Depression
  4. Dyspnoea (difficult or laboured respiration)
  5. Palpitations (feelings or sensations that your heart is pounding or racing)
  6. Adverse drug reaction
  7. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  8. Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)

40-49:

n/a

50-59:

  1. Blood magnesium decreased
  2. Chronic kidney disease
  3. Face oedema (swelling of face)
  4. Pruritus (severe itching of the skin)
  5. Renal failure (kidney dysfunction)
  6. Throat oedema (swelling of throat)
  7. Urticaria (rash of round, red welts on the skin that itch intensely)

60+:

  1. Arthritis (form of joint disorder that involves inflammation of one or more joints)
  2. Difficulty in walking
  3. Bone pain
  4. Drug ineffective
  5. Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)
  6. Groin pain
  7. Local swelling (swelling at the site of some application of substance or injury)
  8. Mobility decreased (ability to move is reduced)
  9. Neck pain
  10. Pain

What are the existing conditions these people have? *

  1. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 4 people, 23.53%
  2. Urinary Tract Infection: 3 people, 17.65%
  3. Birth Control: 3 people, 17.65%
  4. Wheezing (a high-pitched whistling sound made while you breath): 1 person, 5.88%
  5. Stomach Discomfort (pain in abdomen): 1 person, 5.88%
  6. Sinusitis (inflammation of sinus): 1 person, 5.88%
  7. Nausea And Vomiting: 1 person, 5.88%
  8. Nausea (feeling of having an urge to vomit): 1 person, 5.88%
  9. Ill-Defined Disorder: 1 person, 5.88%
  10. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Nicorette and Cephalexin?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Nicorette and Cephalexin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Nicorette:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Cephalexin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Nicorette and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Cephalexin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on nicotine polacrilex and cephalexin (the active ingredients of Nicorette and Cephalexin, respectively), and Nicorette and Cephalexin (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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