Nifedipine and Macrobid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nifedipine (nifedipine) and Macrobid (nitrofurantoin; nitrofurantoin, macrocrystalline). Common drug interactions include mitral valve incompetence among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Nifedipine and Macrobid. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Nifedipine?

Nifedipine has active ingredients of nifedipine. It is often used in high blood pressure. eHealthMe is studying from 53,459 Nifedipine users. Check the latest studies of Nifedipine.

What is Macrobid?

Macrobid has active ingredients of nitrofurantoin; nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 9,215 Macrobid users. Check the latest studies of Macrobid.

On Jul, 07, 2026

62 people who take Nifedipine and Macrobid together, and have interactions are studied.

Nifedipine and Macrobid drug interactions.

What are the common drug interactions of Nifedipine and Macrobid, by gender? *:

female:

Mitral valve incompetence (inefficient heart valve)
Pruritus (severe itching of the skin)
Intestinal obstruction
Arthralgia (joint pain)
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Night sweats (sweating in night)
Osteonecrosis of jaw (death of bone of jaw)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Cardiomegaly (increased size of heart than normal)
Eye pain

male:

Abdominal pain
Agitation (state of anxiety or nervous excitement)
Dyspepsia (indigestion)
Feeling hot
Feeling of body temperature change
Heart rate decreased
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypotension (abnormally low blood pressure)
Muscle spasms (muscle contraction)
Nausea (feeling of having an urge to vomit)

What are the common drug interactions of Nifedipine and Macrobid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Cushingoid (obesity and weakening of the muscles)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Heart rate increased
Joint swelling
Local swelling (swelling at the site of some application of substance or injury)
Muscular weakness (muscle weakness)
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)

30-39:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Catheter site erythema (redness of skin at catheter site)
Catheter site infection (infection at the site of insertion)
Catheter site pain
Dizziness
Fall
Hypotension (abnormally low blood pressure)
Nephrotic syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema)

40-49:

Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic disorder
Aortic valve incompetence
Aphthous stomatitis (mouth ulcer)
Asthenia (weakness)
Asthma
Atelectasis (partial or complete collapse of the lung)

50-59:

International normalised ratio increased
Oedema peripheral (superficial swelling)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)
Respiratory rate increased (excess breathing rate/min)
Speech disorder
Tongue oedema (swelling of tongue)
Tympanic membrane perforation (a break in continuity of ear drum)
Vomiting
Bk virus infection
Blood creatinine decreased

60+:

Anxiety
Erythema (redness of the skin)
Chills (felling of cold)
Deformity (disfigurement)
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Emotional distress
Escherichia infection (bacterial infection by escherichia coli)
Exostosis (formation of new bone on the surface of a bone)
Gingival bleeding (bleeding gums)
Gingival disorder (gum disease)

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 13 people, 20.97%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 14.52%
Pain: 6 people, 9.68%
Fabry's Disease (build up of a particular type of fat, called globotriaosylceramide, in the body's cells): 6 people, 9.68%
Immunodeficiency Common Variable: 5 people, 8.06%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 8.06%
Depression: 5 people, 8.06%
Constipation: 5 people, 8.06%
Nausea (feeling of having an urge to vomit): 4 people, 6.45%
Insomnia (sleeplessness): 4 people, 6.45%

* Approximation only. Some reports may have incomplete information.

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