Nitro-dur and Depakote drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nitro-dur (nitroglycerin) and Depakote (divalproex sodium). Common drug interactions include asthenia among females and blood sodium decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Nitro-dur and Depakote. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Nitro-dur?

Nitro-dur has active ingredients of nitroglycerin. eHealthMe is studying from 2,414 Nitro-dur users. Check the latest studies of Nitro-dur.

What is Depakote?

Depakote has active ingredients of divalproex sodium. It is often used in bipolar disorder. eHealthMe is studying from 55,581 Depakote users. Check the latest studies of Depakote.

On Aug, 08, 2026

15 people who take Nitro-dur and Depakote together, and have interactions are studied.

Nitro-dur and Depakote drug interactions.

What are the common drug interactions of Nitro-Dur and Depakote, by gender? *:

female:

Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac failure congestive
Cardiogenic shock (inadequate circulation of blood)
Cardiomegaly (increased size of heart than normal)
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dyspnoea paroxysmal nocturnal (respiratory distress that awakens patients from sleep)
Hypercoagulation (increased tendency for clotting of the blood)

male:

Blood sodium decreased
Abdominal discomfort
Burn oesophageal (burn in the oesophagus)
Constipation
Muscle cramps (painful sensations caused by muscle contraction)
Nausea (feeling of having an urge to vomit)
Syncope (loss of consciousness with an inability to maintain postural tone)
Urine discolouration
Ventricular fibrillation (abnormally irregular heart rhythm)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)

What are the common drug interactions of Nitro-Dur and Depakote, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Burn oesophageal (burn in the oesophagus)
Constipation
Hemiplegia (paralysis of one side of the body)
Hypoglycaemic unconsciousness (unconsciousness due to low blood sugar)
Inflammation
Migraine (headache)
Muscle cramps (painful sensations caused by muscle contraction)
Nausea (feeling of having an urge to vomit)
Urine discolouration

60+:

Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Hypokalaemia (low potassium)
Multiple injuries
Orthopnoea (shortness of breath (dyspnea) when lying down)
Pleural effusion (water on the lungs)
Pneumonia
Renal failure acute (rapid kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)
Type 2 diabetes mellitus

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 26.67%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 26.67%
Pain: 2 people, 13.33%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 2 people, 13.33%
Insulin-Requiring Type Ii Diabetes Mellitus: 2 people, 13.33%
Hyperkalemia (damage to or disease of the kidney): 2 people, 13.33%
High Blood Cholesterol: 2 people, 13.33%
Gout (uric acid crystals building up in the body): 2 people, 13.33%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 13.33%
Arterial Spasm (temporary, sudden narrowing of one of the coronary arteries): 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

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