Nitrofurantoin and Acyclovir drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nitrofurantoin (nitrofurantoin, macrocrystalline) and Acyclovir (acyclovir). Common drug interactions include major depression among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Nitrofurantoin and Acyclovir. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Nitrofurantoin?

Nitrofurantoin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 4,840 Nitrofurantoin users. Check the latest studies of Nitrofurantoin.

What is Acyclovir?

Acyclovir has active ingredients of acyclovir. It is often used in herpes simplex. eHealthMe is studying from 54,961 Acyclovir users. Check the latest studies of Acyclovir.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

64 people who take Nitrofurantoin and Acyclovir together, and have interactions are studied.

Nitrofurantoin and Acyclovir drug interactions.

What are the common drug interactions of Nitrofurantoin and Acyclovir, by gender? *:

female:

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Nasopharyngitis (inflammation of the nasopharynx)
Obesity (having too much body fat)
Osteonecrosis (death of bone)
Overdose
Pruritus (severe itching of the skin)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Vaginal infection
Vulval cancer stage 0
Vulvar dysplasia (vulval dysplasia means that there are cells that are no longer normal and may be trying to become a cancer)

male:

Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Anaemia (lack of blood)
Cardiac disorder
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic lymphocytic leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell))
Culture urine positive
Diarrhoea
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Lymphadenopathy (disease or enlargement of lymph nodes)

What are the common drug interactions of Nitrofurantoin and Acyclovir, by age (0-1 to 60+)? *:

0-1:

Atelectasis (partial or complete collapse of the lung)
Blood creatinine increased
Productive cough
Pyrexia (fever)
Upper respiratory tract infection
Blood culture positive
Obstructive uropathy (a blockage that prevents urine from leaving your kidneys)
Culture urine positive
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nephropathy toxic (damage to kidney due to toxins)

2-9:

n/a

10-19:

Dyspnoea (difficult or laboured respiration)
Loss of consciousness
Pain
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary infarction (death of a small area of lung)

20-29:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Gallbladder injury
Thrombosis (formation of a blood clot inside a blood vessel)

30-39:

Cervical dysplasia (abnormal changes in the cells on the surface of the cervix)
Vulval cancer stage 0
Vulvar dysplasia (vulval dysplasia means that there are cells that are no longer normal and may be trying to become a cancer)
Genitourinary tract neoplasm (genitourinary tract cancer)
Cd4 lymphocytes decreased
Cd8 lymphocytes decreased
Cervix disorder
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

40-49:

Blood cholesterol increased
Cellulitis (infection under the skin)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Ear disorder
Ear infection
Eye pain
Hyperlipidaemia (presence of excess lipids in the blood)
Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)
Nasopharyngitis (inflammation of the nasopharynx)
Obesity (having too much body fat)

50-59:

Diarrhoea
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Myocarditis (inflammation of heart muscle myocardium)
Nausea (feeling of having an urge to vomit)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)
Vomiting
Asthenia (weakness)
Osteonecrosis of jaw (death of bone of jaw)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
C-reactive protein increased

60+:

Anxiety
Fall
Splenomegaly (enlargement of spleen)
Arthralgia (joint pain)
Back pain
Bone disorder
Dental caries
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dysphonia (speech disorder attributable to a disorder of phonation)
Facial pain

What are the existing conditions these people have? *

Pain: 23 people, 35.94%
Muscle Spasms (muscle contraction): 12 people, 18.75%
Birth Control: 10 people, 15.62%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 8 people, 12.50%
Osteoporosis (bones weak and more likely to break): 6 people, 9.38%
Respiratory Tract Infection: 5 people, 7.81%
Respiratory Tract Congestion (blockage on respiratory system): 5 people, 7.81%
Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 7.81%
Cough: 5 people, 7.81%
Stress And Anxiety: 4 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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