Nitrofurantoin and Enbrel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nitrofurantoin (nitrofurantoin, macrocrystalline) and Enbrel (etanercept). Common drug interactions include papillary thyroid cancer among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Nitrofurantoin and Enbrel. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Nitrofurantoin?

Nitrofurantoin has active ingredients of nitrofurantoin, macrocrystalline. It is often used in urinary tract infection. eHealthMe is studying from 4,837 Nitrofurantoin users. Check the latest studies of Nitrofurantoin.

What is Enbrel?

Enbrel has active ingredients of etanercept. It is often used in rheumatoid arthritis. eHealthMe is studying from 664,678 Enbrel users. Check the latest studies of Enbrel.

On Jul, 31, 2026

74 people who take Nitrofurantoin and Enbrel together, and have interactions are studied.

Nitrofurantoin and Enbrel drug interactions.

What are the common drug interactions of Nitrofurantoin and Enbrel, by gender? *:

female:

Papillary thyroid cancer
Psoriasis (immune-mediated disease that affects the skin)
Pulmonary mass
Pustular psoriasis (raised bumps on the skin that are filled with pus)
Rigors (an episode of shaking or exaggerated shivering)
Sepsis (a severe blood infection that can lead to organ failure and death)
Sinusitis (inflammation of sinus)
Spinal disorder (disease of spine a back bone)
Nausea (feeling of having an urge to vomit)
Headache (pain in head)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Pain
Pyrexia (fever)
Renal colic (renal pain)
Vomiting
Weight decreased
Cholecystitis (infection of gallbladder)
Death
Gallbladder disorder

What are the common drug interactions of Nitrofurantoin and Enbrel, by age (0-1 to 60+)? *:

0-1:

Otitis media (inflammation of the middle ear)

2-9:

Abdominal pain
Accident
Coordination abnormal (abnormal movement)
Diarrhoea
Injury

10-19:

n/a

20-29:

n/a

30-39:

Injection site haemorrhage (bleeding from injection site)

40-49:

Vaginal haemorrhage (vaginal bleeding)
Drug hypersensitivity
Hypoaesthesia (reduced sense of touch or sensation)
Lower respiratory tract infection
Ovarian cyst (fluid filled sac of the ovary)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Thrombocytopenia (decrease of platelets in blood)
Uterine fibroids (benign growths of the muscle inside the uterus)
Weight decreased
Drug maladministration

50-59:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Gait disturbance
Generalised oedema (swelling all over the body)
Hepatic failure (liver failure)
Hypersomnia (excessive daytime sleepiness (eds))
Inguinal hernia (hernia in which a loop of intestine enters the inguinal canal; the most common type of hernia in males)
Injection site bruising
Injection site mass
Lung disorder (lung disease)

60+:

Balance disorder
Headache (pain in head)
Road traffic accident
Vision blurred
Vomiting
Weight decreased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Weight increased
Asthenia (weakness)
Back pain

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 6 people, 8.11%
Pain: 4 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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