1. Home
  2. Analysis
  3. Nitrol
  4. Amitiza

Nitrol and Amitiza drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nitrol (nitroglycerin) and Amitiza (lubiprostone). Common drug interactions include sinusitis among females and gastrointestinal haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Nitrol and Amitiza. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Nitrol?

Nitrol has active ingredients of nitroglycerin. eHealthMe is studying from 3,069 Nitrol users. Check the latest studies of Nitrol.

What is Amitiza?

Amitiza has active ingredients of lubiprostone. It is often used in constipation. eHealthMe is studying from 10,567 Amitiza users. Check the latest studies of Amitiza.

On Jul, 18, 2026

18 people who take Nitrol and Amitiza together, and have interactions are studied.

Nitrol and Amitiza drug interactions.

What are the common drug interactions of Nitrol and Amitiza, by gender? *:

female:

  1. Sinusitis (inflammation of sinus)
  2. Deafness
  3. Heart rate decreased
  4. Post procedural haemorrhage (post procedural bleeding)
  5. Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose)
  6. Tinnitus (a ringing in the ears)
  7. Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
  8. Asthma
  9. Chest pain
  10. Chronic kidney disease

male:

  1. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  2. Haemorrhagic anaemia (anaemia due to excessive bleeding)

What are the common drug interactions of Nitrol and Amitiza, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Chronic kidney disease

60+:

  1. Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
  2. Haemorrhagic anaemia (anaemia due to excessive bleeding)
  3. Post procedural haemorrhage (post procedural bleeding)
  4. Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose)
  5. Sinusitis (inflammation of sinus)
  6. Chest pain

What are the existing conditions these people have? *

  1. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 14 people, 77.78%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 77.78%
  3. Irritable Bowel Syndrome: 2 people, 11.11%
  4. Food Allergy: 2 people, 11.11%
  5. Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 11.11%
  6. Hypersensitivity: 2 people, 11.11%
  7. Infection: 2 people, 11.11%
  8. Inflammation: 2 people, 11.11%
  9. Dry Mouth: 2 people, 11.11%
  10. Migraine (headache): 2 people, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Nitrol and Amitiza?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Nitrol and Amitiza:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Nitrol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Amitiza:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Nitrol and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Amitiza and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on nitroglycerin and lubiprostone (the active ingredients of Nitrol and Amitiza, respectively), and Nitrol and Amitiza (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.