Nitrous oxide and Forane drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nitrous oxide (nitrous oxide) and Forane (isoflurane). Common drug interactions include hyperkalaemia among females and hyperkalaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Nitrous oxide and Forane. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Nitrous oxide?

Nitrous oxide has active ingredients of nitrous oxide. eHealthMe is studying from 1,780 Nitrous oxide users. Check the latest studies of Nitrous oxide.

What is Forane?

Forane has active ingredients of isoflurane. eHealthMe is studying from 1,047 Forane users. Check the latest studies of Forane.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

20 people who take Nitrous oxide and Forane together, and have interactions are studied.

Nitrous oxide and Forane drug interactions.

What are the common drug interactions of Nitrous Oxide and Forane, by gender? *:

female:

Hyperkalaemia (damage to or disease of the kidney)
Carotid artery stenosis (narrowing of carotid artery)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Delayed recovery from anaesthesia
Diaphragm muscle weakness
Fat embolism (fat obstruction due to injury)
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Lethargy (tiredness)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Muscular weakness (muscle weakness)

male:

Hyperkalaemia (damage to or disease of the kidney)
Brain death
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Mydriasis (a dilation of the pupil)
Pulmonary oedema (fluid accumulation in the lungs)
Pupil fixed
Visual impairment
Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Cardiopulmonary failure (cessation of normal circulation of the blood due to failure of the heart to contract)

What are the common drug interactions of Nitrous Oxide and Forane, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Hepatitis (inflammation of the liver)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)

20-29:

Brain death
Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Cardiopulmonary failure (cessation of normal circulation of the blood due to failure of the heart to contract)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Hypertension (high blood pressure)
Hypokinesia (decreased bodily movement)
Hypotension (abnormally low blood pressure)
Lethargy (tiredness)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Mydriasis (a dilation of the pupil)

30-39:

n/a

40-49:

Carotid artery stenosis (narrowing of carotid artery)
Delayed recovery from anaesthesia
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Procedural hypotension
Sinus bradycardia (an unusually slow heartbeat due to heart disease)

50-59:

Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Diaphragm muscle weakness
Muscular weakness (muscle weakness)
Neuromuscular block prolonged
Pernicious anaemia (anaemia due to lack of vitamin b12)
Subacute combined cord degeneration (subacute combined degeneration of the spinal cord is caused by a vitamin b12 deficiency)
Vitamin b12 deficiency

60+:

Fat embolism (fat obstruction due to injury)
Glucose tolerance decreased (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Nausea (feeling of having an urge to vomit)

What are the existing conditions these people have? *

General Anaesthesia: 5 people, 25.00%
Anaesthesia: 2 people, 10.00%
Sinus Bradycardia (an unusually slow heartbeat due to heart disease): 1 person, 5.00%
Procedural Hypotension: 1 person, 5.00%
Neuromuscular Blockade: 1 person, 5.00%
Local Anaesthesia: 1 person, 5.00%
Infiltration Anaesthesia: 1 person, 5.00%
High Blood Pressure: 1 person, 5.00%
Heart Rate Increased: 1 person, 5.00%
Anaesthesia Reversal: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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