Norco and Dayquil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norco (acetaminophen; hydrocodone bitartrate) and Dayquil (acetaminophen; dextromethorphan; pseudoephedrine). Common drug interactions include vaginal haemorrhage among females and disease progression among males.

The phase IV clinical study analyzes what interactions people have when they take Norco and Dayquil. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

What is Dayquil?

Dayquil has active ingredients of acetaminophen; dextromethorphan; pseudoephedrine. It is often used in cold symptoms. eHealthMe is studying from 1,815 Dayquil users. Check the latest studies of Dayquil.

On Jul, 17, 2026

11 people who take Norco and Dayquil together, and have interactions are studied.

What are the common drug interactions of Norco and Dayquil, by gender? *:

female:

Vaginal haemorrhage (vaginal bleeding)
Abdominal pain
Anorectal disorder
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Drug ineffective
Drug level decreased
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hospitalisation
Rectal haemorrhage (bleeding from anus)
Type 2 diabetes mellitus

male:

Disease progression
Neurological symptom (symptoms of nervous system disease)
Pancreatitis (inflammation of pancreas)
Perirectal abscess

What are the common drug interactions of Norco and Dayquil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Neurological symptom (symptoms of nervous system disease)
Pancreatitis (inflammation of pancreas)
Abortion spontaneous (naturally occurring miscarriage)
Ectopic pregnancy (a pregnancy in which the foetus develops outside the uterus, typically in a fallopian tube)
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)
Ovarian cyst (fluid filled sac of the ovary)
Unintended pregnancy (unwanted pregnancies as well as those that are mistimed)
Vaginal haemorrhage (vaginal bleeding)

30-39:

n/a

40-49:

Abdominal pain

50-59:

Perirectal abscess

60+:

Disease progression
Drug ineffective

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 27.27%
Dyspnea (difficult or laboured breathing): 3 people, 27.27%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 27.27%
Nausea (feeling of having an urge to vomit): 3 people, 27.27%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 18.18%
Nasopharyngitis (inflammation of the nasopharynx): 2 people, 18.18%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 18.18%
Cough: 2 people, 18.18%
Diarrhea: 2 people, 18.18%
Drowsiness: 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

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