Norco and Fentanyl transdermal system drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norco (acetaminophen; hydrocodone bitartrate) and Fentanyl transdermal system (fentanyl). Common drug interactions include application site pain among females and drug toxicity among males.

The phase IV clinical study analyzes what interactions people have when they take Norco and Fentanyl transdermal system. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

What is Fentanyl transdermal system?

Fentanyl transdermal system has active ingredients of fentanyl. It is often used in pain. eHealthMe is studying from 5,728 Fentanyl transdermal system users. Check the latest studies of Fentanyl transdermal system.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

81 people who take Norco and Fentanyl transdermal system together, and have interactions are studied.

Norco and Fentanyl transdermal system drug interactions.

What are the common drug interactions of Norco and Fentanyl Transdermal System, by gender? *:

female:

Application site pain
Application site scab (hard coating on the skin formed at application site)
Arthralgia (joint pain)
Bladder disorder
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Loss of consciousness
Splenic rupture
Abdominal distension
Aphasia (damage to the parts of the brain that control language)

male:

Drug toxicity
Depression
Application site scab (hard coating on the skin formed at application site)
Coronary artery bypass
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Drug administration error
Application site pain
Burning sensation
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hyperhidrosis (abnormally increased sweating)

What are the common drug interactions of Norco and Fentanyl Transdermal System, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hyperhidrosis (abnormally increased sweating)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Surgery
Cold sweat
Drug ineffective

30-39:

Abdominal pain upper
Application site pruritus (application site severe itching of the skin)
Application site rash
Application site scab (hard coating on the skin formed at application site)
Bladder disorder
Fibromyalgia (a long-term condition which causes pain all over the body)
Somnolence (a state of near-sleep, a strong desire for sleep)
Blood cholesterol increased
Erectile dysfunction
Libido decreased (loss of interest in sex)

40-49:

Fibromyalgia (a long-term condition which causes pain all over the body)
Fistula (an abnormal connection or passageway between two)
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Haematochezia (passage of stools containing blood)
Haemorrhage (bleeding)
Hallucination (an experience involving the perception of something not present)
Infection
Intestinal obstruction
Palpitations (feelings or sensations that your heart is pounding or racing)
Parkinson's disease

50-59:

Muscle spasms (muscle contraction)
Hypertension (high blood pressure)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Application site pain
Burning sensation
Depression
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Insomnia (sleeplessness)
Loss of consciousness
Nausea (feeling of having an urge to vomit)

60+:

Application site erythema (redness of the skin at application site)
Chest pain
Asthenia (weakness)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dyspnoea (difficult or laboured respiration)
Migraine (headache)
Speech disorder
Acute myocardial infarction (acute heart attack)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Application site pruritus (application site severe itching of the skin)

What are the existing conditions these people have? *

Back Pain: 22 people, 27.16%
Stress And Anxiety: 21 people, 25.93%
Breakthrough Pain: 18 people, 22.22%
Sleep Disorder: 11 people, 13.58%
Procedural Pain: 8 people, 9.88%
Pain In Extremity: 7 people, 8.64%
Depression: 7 people, 8.64%
Neuralgia (pain in one or more nerves): 6 people, 7.41%
Joint Pain: 6 people, 7.41%
Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 7.41%

* Approximation only. Some reports may have incomplete information.

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