Norco and Mavyret drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norco (acetaminophen; hydrocodone bitartrate) and Mavyret (glecaprevir; pibrentasvir). Common drug interactions include aspartate aminotransferase increased among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Norco and Mavyret. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

What is Mavyret?

Mavyret has active ingredients of glecaprevir; pibrentasvir. eHealthMe is studying from 10,533 Mavyret users. Check the latest studies of Mavyret.

On Aug, 08, 2026

50 people who take Norco and Mavyret together, and have interactions are studied.

What are the common drug interactions of Norco and Mavyret, by gender? *:

female:

Aspartate aminotransferase increased
Asthenia (weakness)
Back disorder
Bilirubin conjugated increased
Blood alkaline phosphatase increased
Blood bilirubin increased
Blood bilirubin unconjugated increased
Blood creatine phosphokinase increased
Blood urine present
Bone density decreased

male:

Fatigue (feeling of tiredness)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Hypotension (abnormally low blood pressure)
Loss of consciousness
Red blood cell count decreased
Renal failure (kidney dysfunction)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Anaemia (lack of blood)
Blood creatinine increased
Bone density decreased

What are the common drug interactions of Norco and Mavyret, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood creatinine increased
Bone density decreased
Depression
Dysstasia (difficulty in standing)
Emotional distress
General physical health deterioration (weak health status)
Limb injury
Osteopenia (a condition where bone mineral density is lower than normal)

40-49:

Anxiety disorder
Delirium tremens (a psychotic condition typical of withdrawal in chronic alcoholics)
Fatigue (feeling of tiredness)
Headache (pain in head)
Panic attack
Rash pruritic (redness with itching)
Viral rash

50-59:

Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Immunosuppression
Influenza
Klebsiella test positive
Nodule (a growth of abnormal tissue)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Pyelonephritis (inflammation of kidney caused by bacteria)
Renal failure (kidney dysfunction)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Urinary tract infection

60+:

Dizziness
Abdominal distension
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Haematochezia (passage of stools containing blood)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Abdominal pain
Adenocarcinoma pancreas (cancer of pancreas)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Benign pancreatic neoplasm (benign (non-cancerous) tumours of the pancreatic)

What are the existing conditions these people have? *

Hepatitis C: 22 people, 44.00%
Hiv Infection: 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

Do you take Norco and Mavyret?

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