Norco and Nplate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norco (acetaminophen; hydrocodone bitartrate) and Nplate (romiplostim). Common drug interactions include acute myeloid leukaemia among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Norco and Nplate. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

What is Nplate?

Nplate has active ingredients of romiplostim. It is often used in idiopathic thrombocytopenic purpura (itp). eHealthMe is studying from 17,850 Nplate users. Check the latest studies of Nplate.

On Jul, 05, 2026

33 people who take Norco and Nplate together, and have interactions are studied.

What are the common drug interactions of Norco and Nplate, by gender? *:

female:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Haemoglobin decreased
Platelet count decreased
Fatigue (feeling of tiredness)
Thrombocytopenia (decrease of platelets in blood)
Lymphocyte count decreased
Red blood cell count increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Death
Diarrhoea

male:

Arthralgia (joint pain)
Chills (felling of cold)
Night sweats (sweating in night)
Thrombocytopenia (decrease of platelets in blood)
Upper respiratory tract infection
Abdominal pain
Anaemia (lack of blood)
Aortic valve stenosis (narrowing of the aortic valve)
Cardiac disorder
Foot amputation (loss of foot)

What are the common drug interactions of Norco and Nplate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Drug ineffective
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Impaired work ability
Malaise (a feeling of general discomfort or uneasiness)
Sinusitis (inflammation of sinus)

30-39:

n/a

40-49:

Drug ineffective
Malignant melanoma (skin cancer rises from melancytes)
Muscular weakness (muscle weakness)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)

50-59:

Arthralgia (joint pain)
Chills (felling of cold)
Petechiae (a small red or purple spot caused by bleeding into the skin)
Skin warm
Urticaria (rash of round, red welts on the skin that itch intensely)
Gingival bleeding (bleeding gums)
Joint swelling
Malaise (a feeling of general discomfort or uneasiness)
Night sweats (sweating in night)
Therapeutic response decreased (less preventive response)

60+:

Acute myeloid leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts)
Haemoglobin decreased
Death
Dehydration (dryness resulting from the removal of water)
Foot amputation (loss of foot)
Leukocytosis (increased white blood cells)
Renal failure acute (rapid kidney dysfunction)
Type 2 diabetes mellitus
Arteriovenous malformation
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

What are the existing conditions these people have? *

Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 24 people, 72.73%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 6.06%
Itching: 2 people, 6.06%
Cough: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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