Norco and Odefsey drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norco (acetaminophen; hydrocodone bitartrate) and Odefsey (emtricitabine; rilpivirine hydrochloride; tenofovir alafenamide fumarate). Common drug interactions include anhedonia among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Norco and Odefsey. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

What is Odefsey?

Odefsey has active ingredients of emtricitabine; rilpivirine hydrochloride; tenofovir alafenamide fumarate. It is often used in hiv infection. eHealthMe is studying from 4,605 Odefsey users. Check the latest studies of Odefsey.

On Jul, 08, 2026

20 people who take Norco and Odefsey together, and have interactions are studied.

What are the common drug interactions of Norco and Odefsey, by gender? *:

female:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Ankle fracture
Bone density decreased
Bone loss
Chronic kidney disease
Dysstasia (difficulty in standing)
Impaired work ability
Osteonecrosis (death of bone)

male:

Emotional distress
Anxiety
Pain in extremity
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Decreased activity
Diarrhoea
Fatigue (feeling of tiredness)
Hand fracture
Headache (pain in head)
Left ventricular failure (left ventricle fails to contract forcefully)

What are the common drug interactions of Norco and Odefsey, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood hiv rna increased
Bone density decreased
Emotional distress
Tooth loss

30-39:

n/a

40-49:

Emotional distress
Anxiety
Bone density decreased
Spinal osteoarthritis (joint cartilage loss in spine)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Depression
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteopenia (a condition where bone mineral density is lower than normal)
Pain in extremity
Hand fracture

50-59:

Emotional distress
Renal failure (kidney dysfunction)
Bone density decreased
Haematuria (presence of blood in urine)
Osteomalacia (softening of the bones due to a lack of vitamin d)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Chronic kidney disease

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Ankle fracture
Anxiety
Bone density decreased
Bone loss
Emotional distress
Osteonecrosis (death of bone)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 5.00%
Inflammation: 1 person, 5.00%
Hepatitis C: 1 person, 5.00%
Depression: 1 person, 5.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 5.00%
Asthma: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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