Norco and Pristiq drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norco (acetaminophen; hydrocodone bitartrate) and Pristiq (desvenlafaxine succinate). Common drug interactions include colour blindness among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Norco and Pristiq. It is created by eHealthMe based on reports of 75 people who take the same drugs from the FDA, and is updated regularly.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

What is Pristiq?

Pristiq has active ingredients of desvenlafaxine succinate. It is often used in depression. eHealthMe is studying from 19,555 Pristiq users. Check the latest studies of Pristiq.

On Jul, 21, 2026

75 people who take Norco and Pristiq together, and have interactions are studied.

What are the common drug interactions of Norco and Pristiq, by gender? *:

female:

Colour blindness (inability to view some colour)
Death
Depressed mood
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Dysarthria (speech disorder)
Dyspnoea exertional (breathlessness or shortness of breath)
General physical health deterioration (weak health status)
Heart rate decreased
Heart rate increased
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

male:

Drug ineffective
Dry mouth
Myalgia (muscle pain)
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
Anaemia (lack of blood)
Decreased appetite
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Insomnia (sleeplessness)
Lethargy (tiredness)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

What are the common drug interactions of Norco and Pristiq, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Vaginal haemorrhage (vaginal bleeding)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Antiphospholipid antibodies positive
Arthralgia (joint pain)
Axillary pain
Chest pain
Injury
Pulmonary embolism (blockage of the main artery of the lung)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Dyspnoea exertional (breathlessness or shortness of breath)

40-49:

Nausea (feeling of having an urge to vomit)
Anger
Loss of consciousness
Malaise (a feeling of general discomfort or uneasiness)
Aggression
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Application site burn
Arterial occlusive disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked)
Cardiac failure
Chest pain

50-59:

Immune system disorder
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pain in extremity
Pneumonia
Post-traumatic stress disorder
Rib fracture
Sleep terror (felling of terror in sleep)
Suicidal ideation
Drug ineffective
Headache (pain in head)

60+:

Drug ineffective
Dry mouth
Weight decreased
Renal impairment (severely reduced kidney function)
Abdominal discomfort
Anaemia (lack of blood)
Aphagia (inability or refusal to swallow)
Blood bilirubin increased
Coma (state of unconsciousness lasting more than six hours)
Confusional state

What are the existing conditions these people have? *

Back Pain: 9 people, 12.00%
Nausea (feeling of having an urge to vomit): 8 people, 10.67%
Stress And Anxiety: 7 people, 9.33%
High Blood Pressure: 7 people, 9.33%
Fibromyalgia (a long-term condition which causes pain all over the body): 7 people, 9.33%
Weight Decreased: 6 people, 8.00%
High Blood Cholesterol: 6 people, 8.00%
Headache (pain in head): 6 people, 8.00%
Bladder Disorder: 6 people, 8.00%
Sleep Disorder: 5 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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