Norco and Sofosbuvir drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norco (acetaminophen; hydrocodone bitartrate) and Sofosbuvir (sofosbuvir). Common drug interactions include chronic obstructive pulmonary disease among females and myocardial infarction among males.

The phase IV clinical study analyzes what interactions people have when they take Norco and Sofosbuvir. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

What is Sofosbuvir?

Sofosbuvir has active ingredients of sofosbuvir. eHealthMe is studying from 9,194 Sofosbuvir users. Check the latest studies of Sofosbuvir.

On Jul, 14, 2026

20 people who take Norco and Sofosbuvir together, and have interactions are studied.

What are the common drug interactions of Norco and Sofosbuvir, by gender? *:

female:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Pneumonia
Anaemia (lack of blood)

male:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Drug ineffective
Decreased appetite
Dysgeusia (disorder of the sense of taste)
Gout (uric acid crystals building up in the body)
Hyperkalaemia (damage to or disease of the kidney)
Injection site bruising
Insomnia (sleeplessness)
Pneumonia
Pruritus (severe itching of the skin)

What are the common drug interactions of Norco and Sofosbuvir, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Drug ineffective
Abdominal pain
Anaemia (lack of blood)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)

50-59:

Campylobacter gastroenteritis (infection of gastrointestinal system)
Thrombocytopenia (decrease of platelets in blood)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Pneumonia
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)

60+:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
Gout (uric acid crystals building up in the body)
Hyperkalaemia (damage to or disease of the kidney)
Pneumonia
Stent placement

What are the existing conditions these people have? *

Hepatitis C: 12 people, 60.00%
Hiv Infection: 3 people, 15.00%
Depression: 2 people, 10.00%
High Blood Pressure: 2 people, 10.00%
Headache (pain in head): 1 person, 5.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 5.00%
Asthma: 1 person, 5.00%
Constipation: 1 person, 5.00%
Eye Pain: 1 person, 5.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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