Norco and Trimethoprim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norco (acetaminophen; hydrocodone bitartrate) and Trimethoprim (trimethoprim). Common drug interactions include thyroid disorder among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Norco and Trimethoprim. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

What is Trimethoprim?

Trimethoprim has active ingredients of trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 8,213 Trimethoprim users. Check the latest studies of Trimethoprim.

On Jul, 16, 2026

24 people who take Norco and Trimethoprim together, and have interactions are studied.

Norco and Trimethoprim drug interactions.

What are the common drug interactions of Norco and Trimethoprim, by gender? *:

female:

Thyroid disorder (thyroid diseases)
Multiple allergies (allergy to multiple agents)
Constipation
Decreased appetite
Allergic cough
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Dizziness
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)

male:

Headache (pain in head)
Acidosis (build-up of carbon dioxide in the blood)
Cough
Delirium (wild excitement)
Dyspnoea (difficult or laboured respiration)
Ear pain
Hypoxia (low oxygen in tissues)
Nausea (feeling of having an urge to vomit)
Peripheral vascular disorder
Abdominal distension

What are the common drug interactions of Norco and Trimethoprim, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Abdominal tenderness
Aggression
Body mass index decreased
Cardiac murmur (an heart sound in valve abnormality)
Chest pain
Constipation
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Escherichia sepsis (bacterial infection by escherichia coli)
Fear of disease
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)

40-49:

Asthenia (weakness)
Bedridden
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Visual impairment

50-59:

Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Ear pain
Headache (pain in head)
Hypoxia (low oxygen in tissues)
Lung transplant rejection (failure of lung transplant)
Nausea (feeling of having an urge to vomit)
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)
Pyrexia (fever)
Septic shock (shock due to blood infection)

60+:

Asthma
Cellulitis (infection under the skin)
Constipation
Dizziness
Nausea (feeling of having an urge to vomit)
Allergic cough
Asthenia (weakness)
Diarrhoea
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 7 people, 29.17%
Dyspnea (difficult or laboured breathing): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Norco and Trimethoprim?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously