Norco and Wakix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norco (acetaminophen; hydrocodone bitartrate) and Wakix (pitolisant hydrochloride). Common drug interactions include bone density decreased among females and apathy among males.

The phase IV clinical study analyzes what interactions people have when they take Norco and Wakix. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,063 Norco users. Check the latest studies of Norco.

What is Wakix?

Wakix has active ingredients of pitolisant hydrochloride. eHealthMe is studying from 1,982 Wakix users. Check the latest studies of Wakix.

On Jul, 20, 2026

49 people who take Norco and Wakix together, and have interactions are studied.

What are the common drug interactions of Norco and Wakix, by gender? *:

female:

Bone density decreased
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dental care
Dizziness
Emotional distress
Food craving
Foot fracture
Drug hypersensitivity
Neuralgia (pain in one or more nerves)
Depression

male:

Apathy
Asthma
Blood pressure increased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Deafness
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Depression
Knee arthroplasty
Multiple allergies (allergy to multiple agents)
Neoplasm (tumour)

What are the common drug interactions of Norco and Wakix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Meniere's disease (a disorder of the inner ear that can affect hearing and balance to a varying degree)

30-39:

Cyp2d6 polymorphism
Drug hypersensitivity
Neuralgia (pain in one or more nerves)
Rash
Surgery
Neuropathy peripheral (surface nerve damage)
Serum ferritin decreased

40-49:

Anaemia (lack of blood)
Depression
Disability
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Drug hypersensitivity
Drug ineffective
Hallucination (an experience involving the perception of something not present)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hypertension (high blood pressure)
Hypoaesthesia (reduced sense of touch or sensation)

50-59:

Dyspnoea (difficult or laboured respiration)
Osteoporosis (bones weak and more likely to break)
Ankle fracture
Blood glucose fluctuation
Depression
Drug hypersensitivity
Fatigue (feeling of tiredness)
Influenza
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)

60+:

n/a

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 48 people, 97.96%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 33 people, 67.35%
Drowsiness: 21 people, 42.86%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 4 people, 8.16%
Stress And Anxiety: 3 people, 6.12%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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