Normodyne and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Normodyne (labetalol hydrochloride) and Actos (pioglitazone hydrochloride). Common drug interactions include abdominal pain among females and blood cholesterol increased among males.

The phase IV clinical study analyzes what interactions people have when they take Normodyne and Actos. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Normodyne?

Normodyne has active ingredients of labetalol hydrochloride. eHealthMe is studying from 858 Normodyne users. Check the latest studies of Normodyne.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

On Jul, 07, 2026

19 people who take Normodyne and Actos together, and have interactions are studied.

What are the common drug interactions of Normodyne and Actos, by gender? *:

female:

Abdominal pain
Lymphoid tissue hyperplasia (a rapid increase in the number of normal cells (called lymphocytes) that are contained in lymph nodes)
Pancreatic neoplasm (pancreatic tumour)
Pancreatitis (inflammation of pancreas)
Renal mass (mass in kidney)
Weight decreased
Blood glucose increased
Blood pressure decreased
Dizziness
Headache (pain in head)

male:

Blood cholesterol increased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Ascites (accumulation of fluid in the abdominal cavity)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrioventricular block (heart block)
Back pain
Blood potassium increased
Blood pressure decreased
Chest pain
Haemorrhagic stroke (stroke caused by the rupture of a blood vessel in the brain)

What are the common drug interactions of Normodyne and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Abdominal pain
Lymphoid tissue hyperplasia (a rapid increase in the number of normal cells (called lymphocytes) that are contained in lymph nodes)
Pancreatic neoplasm (pancreatic tumour)
Pancreatitis (inflammation of pancreas)
Renal mass (mass in kidney)
Cardiac failure congestive
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Oedema peripheral (superficial swelling)
Renal failure (kidney dysfunction)

60+:

Blood cholesterol increased
Blood glucose increased
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Ascites (accumulation of fluid in the abdominal cavity)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood potassium increased
Confusion
Cough
Drug effect decreased
Dyspepsia (indigestion)

What are the existing conditions these people have? *

High Blood Pressure: 6 people, 31.58%
High Blood Cholesterol: 5 people, 26.32%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 26.32%
Urinary Tract Infection: 4 people, 21.05%
Stress And Anxiety: 4 people, 21.05%
Pain: 2 people, 10.53%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 10.53%
Dry Skin: 1 person, 5.26%
Bacterial Infection: 1 person, 5.26%
Cardiac Disorder: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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