Normodyne and Zofran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Normodyne (labetalol hydrochloride) and Zofran (ondansetron hydrochloride). Common drug interactions include pleural effusion among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Normodyne and Zofran. It is created by eHealthMe based on reports of 79 people who take the same drugs from the FDA, and is updated regularly.

What is Normodyne?

Normodyne has active ingredients of labetalol hydrochloride. eHealthMe is studying from 858 Normodyne users. Check the latest studies of Normodyne.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

79 people who take Normodyne and Zofran together, and have interactions are studied.

What are the common drug interactions of Normodyne and Zofran, by gender? *:

female:

Pleural effusion (water on the lungs)
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously)
Pruritus (severe itching of the skin)
Radiculitis brachial (inflammation of the spinal nerve roots of brachial plexus)
Radiculopathy (a set of conditions in which one or more nerves is affected and does not work properly)
Spinal osteoarthritis (joint cartilage loss in spine)
Spondylolisthesis (displacement of a vertebra or the vertebral column in relation to the vertebrae below)
Stomatitis (inflammation of mucous membrane of mouth)
Synovial cyst (cyst of joint filled with synovial fluid)
Temperature intolerance (inability to go in temperature)

male:

Anaemia (lack of blood)
Death
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Weight bearing difficulty (difficulty due to weight of thigh fat deposition)
Anal abscess
Cellulitis (infection under the skin)
Chronic kidney disease
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Genital abscess (build up of pus in genital)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)

What are the common drug interactions of Normodyne and Zofran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cardiac arrest
Hyperglycaemia (high blood sugar)
Haematocrit decreased
Haemoglobin decreased
Headache (pain in head)
Memory impairment
Thirst
Visual impairment

30-39:

Ectopic pregnancy (a pregnancy in which the foetus develops outside the uterus, typically in a fallopian tube)
Anaemia (lack of blood)
Hip arthroplasty
Hyperkalaemia (damage to or disease of the kidney)
Hypoxia (low oxygen in tissues)
Leukopenia (less number of white blood cells in blood)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Weight bearing difficulty (difficulty due to weight of thigh fat deposition)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pulmonary embolism (blockage of the main artery of the lung)

40-49:

Abdominal distension
Abdominal pain
Device dislocation
Dysmenorrhoea (painful menstruation)
Fatigue (feeling of tiredness)
Lymphocyte count decreased
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Migraine (headache)
Uterine haemorrhage (uterine bleeding)
Acute respiratory failure

50-59:

Deformity (disfigurement)
Depression
Drug ineffective
Dry eye (lack of adequate tears)
Dry mouth
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Emotional distress
Fatigue (feeling of tiredness)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

60+:

Death
Malignant hypertension (a hypertensive emergency is a condition in which elevated blood pressure results in target organ damage)
Subdural haematoma (blood collects between the skull and the surface of the brain)
Acute respiratory failure
Anaemia (lack of blood)
Jugular vein distension (overloaded jugular vein)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Pneumonia
Pneumonia staphylococcal (pneumonia staphylococcal infections are usually caused by the organism staphylococcus aureus)

What are the existing conditions these people have? *

Pain: 18 people, 22.78%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 13 people, 16.46%
High Blood Pressure: 13 people, 16.46%
Headache (pain in head): 9 people, 11.39%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 11.39%
Type 2 Diabetes: 7 people, 8.86%
Breast Cancer: 7 people, 8.86%
Nausea And Vomiting: 7 people, 8.86%
Hypotension (abnormally low blood pressure): 7 people, 8.86%
Constipation: 6 people, 7.59%

* Approximation only. Some reports may have incomplete information.

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