Noroxin and Bactrim drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Noroxin (norfloxacin) and Bactrim (sulfamethoxazole; trimethoprim). Common drug interactions include fatigue among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Noroxin and Bactrim. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Noroxin?

Noroxin has active ingredients of norfloxacin. It is often used in urinary tract infection. eHealthMe is studying from 1,675 Noroxin users. Check the latest studies of Noroxin.

What is Bactrim?

Bactrim has active ingredients of sulfamethoxazole; trimethoprim. It is often used in urinary tract infection. eHealthMe is studying from 89,117 Bactrim users. Check the latest studies of Bactrim.

On Aug, 07, 2026

50 people who take Noroxin and Bactrim together, and have interactions are studied.

What are the common drug interactions of Noroxin and Bactrim, by gender? *:

female:

Fatigue (feeling of tiredness)
Fracture
Gamma-glutamyltransferase increased
Hepatocellular damage (liver damage)
Hypokalaemia (low potassium)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Immune system disorder
Insomnia (sleeplessness)
Leukopenia (less number of white blood cells in blood)
Malaise (a feeling of general discomfort or uneasiness)

male:

Abdominal pain
Abnormal behaviour
Lethargy (tiredness)
Nervousness
Prostate cancer
Pyrexia (fever)
Antibiotic associated colitis
Blood creatinine increased
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Cheilitis (infection of lips)

What are the common drug interactions of Noroxin and Bactrim, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cheilitis (infection of lips)
Conjunctivitis (pink eye)
Erythema multiforme (a type of hypersensitivity reaction)
Pyrexia (fever)

30-39:

Blood creatinine increased
Leukopenia (less number of white blood cells in blood)
Lymphadenopathy (disease or enlargement of lymph nodes)

40-49:

Blood creatinine increased
Drug hypersensitivity

50-59:

Aspartate aminotransferase increased
Hepatocellular damage (liver damage)
Leukopenia (less number of white blood cells in blood)
Nausea (feeling of having an urge to vomit)
Pancreatitis (inflammation of pancreas)
Tachypnoea (a condition of rapid breathing over 20 per minute)
Thrombocytopenic purpura (a bleeding disorder in which the immune system destroys platelets)
Lactic acidosis (low ph in body tissues)
Pancreatitis acute (sudden inflammation of pancreas)
Hepatitis (inflammation of the liver)

60+:

Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Odynophagia (painful swallowing, in the mouth (oropharynx) or oesophagus)
Libido increased (increased sexual urge to have sex)
Pruritus (severe itching of the skin)
Pyrexia (fever)
Thrombocythaemia (an increased number of platelets in the circulating blood)
Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Renal failure (kidney dysfunction)
Acute generalised exanthematous pustulosis (acute febrile drug eruption)

What are the existing conditions these people have? *

Gastritis (inflammation of stomach): 6 people, 12.00%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 5 people, 10.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 5 people, 10.00%
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection): 5 people, 10.00%
Type 2 Diabetes: 4 people, 8.00%
Pain: 4 people, 8.00%
Chronic Thyroiditis (long lasting inflammation of thyroid gland): 4 people, 8.00%
Multiple Myeloma (cancer of the plasma cells): 3 people, 6.00%
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract): 3 people, 6.00%
High Blood Pressure: 3 people, 6.00%

* Approximation only. Some reports may have incomplete information.

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