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Northera and Cevimeline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Northera (droxidopa) and Cevimeline (cevimeline hydrochloride). Common drug interactions include blood pressure decreased among females and neuropathy peripheral among males.

The phase IV clinical study analyzes what interactions people have when they take Northera and Cevimeline. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Northera?

Northera has active ingredients of droxidopa. eHealthMe is studying from 22,874 Northera users. Check the latest studies of Northera.

What is Cevimeline?

Cevimeline has active ingredients of cevimeline hydrochloride. It is often used in sjogren syndrome. eHealthMe is studying from 1,480 Cevimeline users. Check the latest studies of Cevimeline.

On Jul, 19, 2026

11 people who take Northera and Cevimeline together, and have interactions are studied.

Northera and Cevimeline drug interactions.

What are the common drug interactions of Northera and Cevimeline, by gender? *:

female:

  1. Blood pressure decreased
  2. Parkinson's disease
  3. Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)

male:

  1. Neuropathy peripheral (surface nerve damage)
  2. Pain
  3. Unresponsive to stimuli
  4. Rash pruritic (redness with itching)
  5. Urticaria (rash of round, red welts on the skin that itch intensely)
  6. Stem cell transplant
  7. Diastolic dysfunction
  8. Blood pressure fluctuation
  9. Fall
  10. Loss of consciousness

What are the common drug interactions of Northera and Cevimeline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Blood pressure decreased

50-59:

n/a

60+:

  1. Neuropathy peripheral (surface nerve damage)
  2. Stem cell transplant
  3. Pain
  4. Diastolic dysfunction

What are the existing conditions these people have? *

  1. Multiple Myeloma (cancer of the plasma cells): 6 people, 54.55%
  2. Parkinson's Disease: 2 people, 18.18%
  3. Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 2 people, 18.18%
  4. Hypotension (abnormally low blood pressure): 1 person, 9.09%
  5. Hypokalemia (low potassium): 1 person, 9.09%
  6. Autonomic Neuropathy (malfunction of the autonomic nervous system (ans)): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Northera and Cevimeline?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Northera and Cevimeline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Northera:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Cevimeline:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Northera and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Cevimeline and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on droxidopa and cevimeline hydrochloride (the active ingredients of Northera and Cevimeline, respectively), and Northera and Cevimeline (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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