Northera and Hydroxyzine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Northera (droxidopa) and Hydroxyzine (hydroxyzine hydrochloride). Common drug interactions include fatigue among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Northera and Hydroxyzine. It is created by eHealthMe based on reports of 33 people who take the same drugs from the FDA, and is updated regularly.

What is Northera?

Northera has active ingredients of droxidopa. eHealthMe is studying from 22,874 Northera users. Check the latest studies of Northera.

What is Hydroxyzine?

Hydroxyzine has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 54,070 Hydroxyzine users. Check the latest studies of Hydroxyzine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

33 people who take Northera and Hydroxyzine together, and have interactions are studied.

Northera and Hydroxyzine drug interactions.

What are the common drug interactions of Northera and Hydroxyzine, by gender? *:

female:

Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Migraine (headache)
Drug ineffective
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Blood pressure fluctuation
Headache (pain in head)
Cardiac amyloidosis (protein deposition in heart)
Dizziness
Palpitations (feelings or sensations that your heart is pounding or racing)

male:

Dizziness
Abdominal distension
Pallor
Tremor (trembling or shaking movements in one or more parts of your body)
Confusional state
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Hallucination (an experience involving the perception of something not present)
Nausea (feeling of having an urge to vomit)
Neck pain

What are the common drug interactions of Northera and Hydroxyzine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood pressure decreased
Blood pressure increased
Chest pain
Dyspnoea (difficult or laboured respiration)
Heart rate decreased
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Vertigo

30-39:

Blood pressure fluctuation
Drug ineffective
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Migraine (headache)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Dizziness

40-49:

Weight increased
Ataxia (loss of full control of bodily movements)
Cardiac failure acute
Chest discomfort
Dehydration (dryness resulting from the removal of water)
Dizziness
Hypoaesthesia (reduced sense of touch or sensation)
Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)
Presyncope

50-59:

Confusional state
Hallucination (an experience involving the perception of something not present)

60+:

Death
Cardiac amyloidosis (protein deposition in heart)
Diarrhoea
Flatulence (flatus expelled through the anus)
Gastrointestinal hypomotility (less activity of the intestinal tract)
Pneumonia
Headache (pain in head)
Weight decreased
Dizziness
Drug ineffective

What are the existing conditions these people have? *

Orthostatic Hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up): 18 people, 54.55%
Hypotension (abnormally low blood pressure): 7 people, 21.21%
Autonomic Neuropathy (malfunction of the autonomic nervous system (ans)): 4 people, 12.12%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 12.12%
Fainting (loss of consciousness and postural tone): 3 people, 9.09%
Nausea And Vomiting: 2 people, 6.06%
Nausea (feeling of having an urge to vomit): 2 people, 6.06%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 6.06%
Migraine (headache): 2 people, 6.06%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

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