Novalgin and Piperacillin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Novalgin (metamizole) and Piperacillin (piperacillin sodium). Common drug interactions include stevens-johnson syndrome among females and pyrexia among males.

The phase IV clinical study analyzes what interactions people have when they take Novalgin and Piperacillin. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Novalgin?

Novalgin has active ingredients of metamizole. It is often used in pain. eHealthMe is studying from 10,177 Novalgin users. Check the latest studies of Novalgin.

What is Piperacillin?

Piperacillin has active ingredients of piperacillin sodium. eHealthMe is studying from 5,597 Piperacillin users. Check the latest studies of Piperacillin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

50 people who take Novalgin and Piperacillin together, and have interactions are studied.

Novalgin and Piperacillin drug interactions.

What are the common drug interactions of Novalgin and Piperacillin, by gender? *:

female:

Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Rash
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Urticaria (rash of round, red welts on the skin that itch intensely)
General physical health deterioration (weak health status)
Cardiac failure
Malignant neoplasm progression (cancer tumour came back)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Dyspnoea (difficult or laboured respiration)

male:

Pyrexia (fever)
Anaemia (lack of blood)
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Hypoxia (low oxygen in tissues)
Pneumonia influenzal (the flu with pneumonia)
Radiation skin injury
Restlessness (not able to rest)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

What are the common drug interactions of Novalgin and Piperacillin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Metastatic squamous cell carcinoma (cancer of squamous cells spreads to other part)

30-39:

General physical health deterioration (weak health status)

40-49:

Pyrexia (fever)
Aphasia (damage to the parts of the brain that control language)
Blood bilirubin increased
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Hypoxia (low oxygen in tissues)
Pneumonia influenzal (the flu with pneumonia)
Restlessness (not able to rest)
Sepsis (a severe blood infection that can lead to organ failure and death)
Somnolence (a state of near-sleep, a strong desire for sleep)

50-59:

n/a

60+:

Anaemia (lack of blood)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Infection
Pyrexia (fever)
General physical health deterioration (weak health status)
Thrombocytopenia (decrease of platelets in blood)
Radiation skin injury
Tumour lysis syndrome (a group of metabolic complications that can occur after treatment of cancer, these complications are caused by the breakdown products of dying cancer cells)
C-reactive protein increased
Cardiac failure

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 17 people, 34.00%
High Blood Pressure: 15 people, 30.00%
Nausea (feeling of having an urge to vomit): 12 people, 24.00%
Urinary Tract Infection: 11 people, 22.00%
High Blood Cholesterol: 9 people, 18.00%
Urination - Excessive Volume: 9 people, 18.00%
Cardiac Failure: 8 people, 16.00%
Heart Attack: 8 people, 16.00%
Oedema (fluid collection in tissue): 6 people, 12.00%
Small Intestinal Perforation (hole in small intestine): 6 people, 12.00%

* Approximation only. Some reports may have incomplete information.

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