Novantrone and Hydrochlorothiazide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Novantrone (mitoxantrone hydrochloride) and Hydrochlorothiazide (hydrochlorothiazide). Common drug interactions include chronic myeloid leukaemia among females and pancytopenia among males.

The phase IV clinical study analyzes what interactions people have when they take Novantrone and Hydrochlorothiazide. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Novantrone?

Novantrone has active ingredients of mitoxantrone hydrochloride. It is often used in multiple sclerosis. eHealthMe is studying from 3,349 Novantrone users. Check the latest studies of Novantrone.

What is Hydrochlorothiazide?

Hydrochlorothiazide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 182,194 Hydrochlorothiazide users. Check the latest studies of Hydrochlorothiazide.

On Aug, 01, 2026

25 people who take Novantrone and Hydrochlorothiazide together, and have interactions are studied.

Novantrone and Hydrochlorothiazide drug interactions.

What are the common drug interactions of Novantrone and Hydrochlorothiazide, by gender? *:

female:

Chronic myeloid leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood)
Pain in extremity
Cardiac murmur (an heart sound in valve abnormality)
Cardiomyopathy (weakening of the heart muscle)
Electrocardiogram t wave inversion
Pruritus (severe itching of the skin)
Nausea (feeling of having an urge to vomit)
Vomiting
Abnormal loss of weight
Arthralgia (joint pain)

male:

Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Respiratory failure (excl neonatal) (inadequate gas exchange by the respiratory system(excluding neonatal))
Blood culture positive
Blood glucose increased
Blood pressure diastolic decreased
Blood pressure systolic increased
Blood urea increased
Cellulitis (infection under the skin)
Chest pain
Dyspnoea exertional (breathlessness or shortness of breath)

What are the common drug interactions of Novantrone and Hydrochlorothiazide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Premature menopause
Vomiting
Dizziness
Loss of consciousness
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Pain in extremity
Cardiac murmur (an heart sound in valve abnormality)
Chronic myeloid leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood)
Electrocardiogram t wave inversion
Feeling hot

40-49:

Chronic myeloid leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood)
Pruritus (severe itching of the skin)
Arthralgia (joint pain)
Cardiac murmur (an heart sound in valve abnormality)
Chills (felling of cold)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Dyspnoea (difficult or laboured respiration)
Electrocardiogram t wave inversion
Fall

50-59:

Cardiomyopathy (weakening of the heart muscle)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Septic shock (shock due to blood infection)
Abnormal loss of weight
Cardiac failure
Calculus bladder (bladder stone)
Cardiac failure congestive
Dysphagia (a condition in which swallowing is difficult or painful)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Failure to thrive (inadequate weight gain and physical growth in children)

60+:

Respiratory failure (excl neonatal) (inadequate gas exchange by the respiratory system(excluding neonatal))
Haematocrit decreased
Blood pressure systolic increased
Blood urea increased
Cellulitis (infection under the skin)
Chest pain
Dyspnoea exertional (breathlessness or shortness of breath)
Febrile neutropenia (fever with reduced white blood cells)
Lymphocyte count decreased
Neutropenia (an abnormally low number of neutrophils)

What are the existing conditions these people have? *

Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 3 people, 12.00%
Secondary Progressive Multiple Sclerosis (a stage of ms which comes after relapsing remitting ms in many cases): 2 people, 8.00%
Prostate Cancer Metastatic: 2 people, 8.00%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 2 people, 8.00%
Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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