Nplate and Centrum drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nplate (romiplostim) and Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e). Common drug interactions include musculoskeletal pain among females and thrombocytopenia among males.

The phase IV clinical study analyzes what interactions people have when they take Nplate and Centrum. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Nplate?

Nplate has active ingredients of romiplostim. It is often used in idiopathic thrombocytopenic purpura (itp). eHealthMe is studying from 17,850 Nplate users. Check the latest studies of Nplate.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,686 Centrum users. Check the latest studies of Centrum.

On Aug, 10, 2026

40 people who take Nplate and Centrum together, and have interactions are studied.

What are the common drug interactions of Nplate and Centrum, by gender? *:

female:

Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Myalgia (muscle pain)
Neutropenia (an abnormally low number of neutrophils)
Non-cardiac chest pain
Oedema peripheral (superficial swelling)
Platelet count increased
Procedural pain
Pruritus (severe itching of the skin)
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Tooth disorder (tooth disease)

male:

Thrombocytopenia (decrease of platelets in blood)
Diarrhoea
Mesenteric vein thrombosis (blood clot in mesenteric vein)
Pancreatitis (inflammation of pancreas)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Multiple myeloma (cancer of the plasma cells)
Pain in extremity
Pyrexia (fever)
Subdural haematoma (blood collects between the skull and the surface of the brain)

What are the common drug interactions of Nplate and Centrum, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Leukaemia (blood or bone marrow cancer)
White blood cell count increased
Cough
Drug ineffective
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Oropharyngeal pain
Rash
Leukocytosis (increased white blood cells)

40-49:

Hepatic enzyme increased
Portal vein thrombosis (venous thrombosis affecting the hepatic portal vein)
Pulmonary embolism (blockage of the main artery of the lung)
Thrombocythaemia (an increased number of platelets in the circulating blood)
Diarrhoea
Hepatic vein thrombosis (obstruction in the veins of the liver caused by a blood clot)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Malaise (a feeling of general discomfort or uneasiness)
Mesenteric vein thrombosis (blood clot in mesenteric vein)
Oedema peripheral (superficial swelling)

50-59:

Arthralgia (joint pain)
Myalgia (muscle pain)
Trigger finger

60+:

Thrombocytopenia (decrease of platelets in blood)
Pain in extremity
Anaemia (lack of blood)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bone marrow failure
Cardiac arrest
Disease progression
Dizziness
Dysarthria (speech disorder)
Febrile neutropenia (fever with reduced white blood cells)

What are the existing conditions these people have? *

Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 34 people, 85.00%

* Approximation only. Some reports may have incomplete information.

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