Nplate and Cytoxan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nplate (romiplostim) and Cytoxan (cyclophosphamide). Common drug interactions include epistaxis among females and oedema among males.

The phase IV clinical study analyzes what interactions people have when they take Nplate and Cytoxan. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Nplate?

Nplate has active ingredients of romiplostim. It is often used in idiopathic thrombocytopenic purpura (itp). eHealthMe is studying from 17,850 Nplate users. Check the latest studies of Nplate.

What is Cytoxan?

Cytoxan has active ingredients of cyclophosphamide. It is often used in breast cancer. eHealthMe is studying from 19,693 Cytoxan users. Check the latest studies of Cytoxan.

On Aug, 10, 2026

24 people who take Nplate and Cytoxan together, and have interactions are studied.

What are the common drug interactions of Nplate and Cytoxan, by gender? *:

female:

Epistaxis (bleed from the nose)
Thrombocytopenia (decrease of platelets in blood)
Contusion (a type of hematoma of tissue in which capillaries)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Erythema (redness of the skin)
Platelet count decreased
Urinary tract infection
Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Acute myocardial infarction (acute heart attack)
Adverse drug reaction

male:

Oedema (fluid collection in tissue)
Drug ineffective
Constipation
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Glycosylated haemoglobin increased
Haemolytic anaemia (anaemia due to haemolysis)
Haemorrhage (bleeding)
Headache (pain in head)
Lymphoma (cancer that begins in immune system cells)

What are the common drug interactions of Nplate and Cytoxan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Acute coronary syndrome (acute chest pain and other symptoms that happen because the heart does not get blood)
Acute myocardial infarction (acute heart attack)
Adverse drug reaction
Back pain
Blood pressure increased
Cardiac failure congestive
Coronary artery thrombosis (clot formation in coronary artery)
Dyspnoea paroxysmal nocturnal (respiratory distress that awakens patients from sleep)
Epistaxis (bleed from the nose)
Fluid overload (too much fluid in the blood)

50-59:

n/a

60+:

Drug ineffective
Thrombocytopenia (decrease of platelets in blood)
Connective tissue disorder (any disease that has the connective tissues of the body)
Constipation
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Depression
Drug effect decreased
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)

What are the existing conditions these people have? *

Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 22 people, 91.67%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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