Nplate and Doxycycline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nplate (romiplostim) and Doxycycline (doxycycline hyclate). Common drug interactions include oedema peripheral among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Nplate and Doxycycline. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Nplate?

Nplate has active ingredients of romiplostim. It is often used in idiopathic thrombocytopenic purpura (itp). eHealthMe is studying from 17,850 Nplate users. Check the latest studies of Nplate.

What is Doxycycline?

Doxycycline has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 60,868 Doxycycline users. Check the latest studies of Doxycycline.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

20 people who take Nplate and Doxycycline together, and have interactions are studied.

Nplate and Doxycycline drug interactions.

What are the common drug interactions of Nplate and Doxycycline, by gender? *:

female:

Oedema peripheral (superficial swelling)
Pain in extremity
Petechiae (a small red or purple spot caused by bleeding into the skin)
Pleural effusion (water on the lungs)
Pulmonary embolism (blockage of the main artery of the lung)
Purpura (purplish discoloration of the skin)
Skin exfoliation (removal of the oldest dead skin cells)
Skin hyperpigmentation (disorders affect the colour of your skin)
Skin ulcer
Tremor (trembling or shaking movements in one or more parts of your body)

male:

Diarrhoea
Weight decreased
Asthenia (weakness)
Cardiac disorder
Cardiomyopathy (weakening of the heart muscle)
Chest pain
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Congestive cardiomyopathy (weakening of heart muscle)
Decreased appetite
Dizziness

What are the common drug interactions of Nplate and Doxycycline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Acute respiratory distress syndrome
Aortic arteriosclerosis (hardening of the aortic arteries)
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Cardiac valve vegetation (heart valve abnormal growth)
Cell death
Focal segmental glomerulosclerosis (scar tissue that forms in parts of the kidney called glomeruli)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Interstitial lung disease
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)

40-49:

Vomiting
Weight increased
Wheezing (a high-pitched whistling sound made while you breath)
Lupus-like syndrome (a disease symptom matches with lupus an immune disease)
Rash
Skin hypopigmentation (loss of skin colour)
Anxiety
Insomnia (sleeplessness)
Pain
Acarodermatitis (skin inflammation caused by mites (acarids))

50-59:

Hiv infection
Idiopathic thrombocytopenic purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting)
Non-hodgkin's lymphoma (malignant (cancer) cells form in the lymph system)
Adverse drug reaction
Bradycardia (abnormally slow heart action)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Constipation
Depressed mood
Diarrhoea
Drug ineffective

60+:

Diarrhoea
Pulmonary embolism (blockage of the main artery of the lung)
Decreased appetite
Dizziness
Embolism (obstruction of an artery, typically by a clot of blood or an air bubble)
Fatigue (feeling of tiredness)
Influenza like illness
Pneumonia
Renal failure acute (rapid kidney dysfunction)
Upper respiratory tract infection

What are the existing conditions these people have? *

Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 14 people, 70.00%
Hiv Infection: 3 people, 15.00%
Thrombocytopenia (decrease of platelets in blood): 2 people, 10.00%
Periodontal Disease (disease that attacks the gum and bone and around the teeth): 1 person, 5.00%
Bronchial Carcinoma (lung cancer): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Nplate and Doxycycline?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously