Nplate and Soliris drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nplate (romiplostim) and Soliris (eculizumab). Common drug interactions include platelet count decreased among females and brain herniation among males.

The phase IV clinical study analyzes what interactions people have when they take Nplate and Soliris. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Nplate?

Nplate has active ingredients of romiplostim. It is often used in idiopathic thrombocytopenic purpura (itp). eHealthMe is studying from 17,850 Nplate users. Check the latest studies of Nplate.

What is Soliris?

Soliris has active ingredients of eculizumab. It is often used in paroxysmal nocturnal hemoglobinuria (pnh). eHealthMe is studying from 58,821 Soliris users. Check the latest studies of Soliris.

On Jul, 06, 2026

11 people who take Nplate and Soliris together, and have interactions are studied.

What are the common drug interactions of Nplate and Soliris, by gender? *:

female:

Platelet count decreased
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Dyspnoea (difficult or laboured respiration)
Klebsiella infection
Nausea (feeling of having an urge to vomit)
General physical health deterioration (weak health status)
Leukopenia (less number of white blood cells in blood)
Neutropenia (an abnormally low number of neutrophils)
Abdominal pain upper
Arteriosclerosis (thickening and hardening of arteries)

male:

Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Cerebral thrombosis (blood clot in brain)
Endocarditis (inflammation in heart muscle)
Gonorrhoea (a common human sexually transmitted infection caused by the bacterium neisseria gonorrhoea)
Infection
Splenic vein thrombosis (blood clot in splenic vein)
Wound infection

What are the common drug interactions of Nplate and Soliris, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Vomiting
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)
Arrhythmia (irregular heartbeat)
Bedridden
Blood culture positive
Cardiac arrest
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Device related infection
Dizziness
Encephalopathy (functioning of the brain is affected by some agent or condition)

40-49:

n/a

50-59:

Leukopenia (less number of white blood cells in blood)
Neutropenia (an abnormally low number of neutrophils)
Aplastic anaemia (blood disorder in which the body's bone marrow doesn't make enough new blood cells)

60+:

Abdominal pain upper
Arteriosclerosis (thickening and hardening of arteries)
Fluid overload (too much fluid in the blood)
Headache (pain in head)
Hepatosplenomegaly (enlargement of both the liver and the spleen)
Hyperkalaemia (damage to or disease of the kidney)
Hypoxia (low oxygen in tissues)
Impaired gastric emptying
Middle ear effusion (fluid in middle ear)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

What are the existing conditions these people have? *

Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 6 people, 54.55%
Haemolytic Uraemic Syndrome (blood clotting disease caused by e. coli infection, birth control pills, pneumonia, medications, and more): 3 people, 27.27%
Thrombocytopenia (decrease of platelets in blood): 3 people, 27.27%
Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 3 people, 27.27%
Aplastic Anemia: 2 people, 18.18%
Pain: 2 people, 18.18%
Indigestion: 1 person, 9.09%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 9.09%
Haemoglobin Decreased: 1 person, 9.09%
Haemorrhage (bleeding): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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