Nucynta er and Linzess drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nucynta er (tapentadol hydrochloride) and Linzess (linaclotide). Common drug interactions include decreased appetite among females and depression among males.

The phase IV clinical study analyzes what interactions people have when they take Nucynta er and Linzess. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Nucynta er?

Nucynta er has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 2,508 Nucynta er users. Check the latest studies of Nucynta er.

What is Linzess?

Linzess has active ingredients of linaclotide. It is often used in constipation. eHealthMe is studying from 24,086 Linzess users. Check the latest studies of Linzess.

On Jul, 17, 2026

18 people who take Nucynta er and Linzess together, and have interactions are studied.

Nucynta er and Linzess drug interactions.

What are the common drug interactions of Nucynta Er and Linzess, by gender? *:

female:

Decreased appetite
Drug ineffective
Formication (a sensation that exactly resembles that of small insects crawling on (or under) the skin)
Headache (pain in head)
Pain in extremity
Weight decreased
Fatigue (feeling of tiredness)
Jc virus infection
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Acute polyneuropathy (acute illness where sensory and motor nerves of the peripheral nervous system are affected)

male:

Depression
Hospitalisation
White blood cell count increased
Muscular weakness (muscle weakness)
Opiates positive
Asthenia (weakness)
Diarrhoea
Drug screen positive
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hypersensitivity

What are the common drug interactions of Nucynta Er and Linzess, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Diarrhoea
Insomnia (sleeplessness)

30-39:

n/a

40-49:

n/a

50-59:

Drug ineffective
Fatigue (feeling of tiredness)

60+:

Blood gases
Fall
Drug screen positive
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Infection
Intervertebral disc protrusion (spinal disc protrusion)
Rectal prolapse (falling of rectum from normal place)
Somnolence (a state of near-sleep, a strong desire for sleep)
White blood cell count increased
Muscular weakness (muscle weakness)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 50.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 38.89%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 16.67%
Gait Disturbance: 3 people, 16.67%
Stress And Anxiety: 2 people, 11.11%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 2 people, 11.11%
Pain In Extremity: 2 people, 11.11%
Breakthrough Pain: 2 people, 11.11%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 1 person, 5.56%
Depression: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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