Nucynta and Fluoxetine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nucynta (tapentadol hydrochloride) and Fluoxetine (fluoxetine hydrochloride). Common drug interactions include increased tendency to bruise among females and loss of consciousness among males.

The phase IV clinical study analyzes what interactions people have when they take Nucynta and Fluoxetine. It is created by eHealthMe based on reports of 81 people who take the same drugs from the FDA, and is updated regularly.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

What is Fluoxetine?

Fluoxetine has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 98,824 Fluoxetine users. Check the latest studies of Fluoxetine.

On Aug, 04, 2026

81 people who take Nucynta and Fluoxetine together, and have interactions are studied.

Nucynta and Fluoxetine drug interactions.

What are the common drug interactions of Nucynta and Fluoxetine, by gender? *:

female:

Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Loss of consciousness
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pregnancy on oral contraceptive
Sinusitis (inflammation of sinus)
Syncope (loss of consciousness with an inability to maintain postural tone)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Therapeutic response unexpected
Tibia fracture (fracture of lower leg bone)
Abasia (inability to walk)

male:

Loss of consciousness
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Renal impairment (severely reduced kidney function)
Somnolence (a state of near-sleep, a strong desire for sleep)
Sudden onset of sleep
Weight decreased
Renal failure (kidney dysfunction)
Abasia (inability to walk)
Injury
Haemoglobin decreased

What are the common drug interactions of Nucynta and Fluoxetine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Arthropathy
Bone disorder
Bone pain
Cataract (clouding of the lens inside the eye)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Fracture delayed union (delayed cure of broken bone)
Humerus fracture (injury to the upper arm bone)
Osteoporosis (bones weak and more likely to break)
Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Upper limb fracture

20-29:

Agitation (state of anxiety or nervous excitement)
Coma (state of unconsciousness lasting more than six hours)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Hyporeflexia (a condition of below normal or absent reflexes)
Loss of consciousness
Pyrexia (fever)
Rash
Respiratory rate decreased (less breathing rate/min)
Restlessness (not able to rest)
Somnolence (a state of near-sleep, a strong desire for sleep)

30-39:

Abnormal behaviour
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Deafness bilateral
Hallucinations, mixed (sensations that appear real but are created by your mind -mixed)
Abdominal pain upper
Drug ineffective
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Endometriosis (appearance of endometrial tissue outside the uterus and causing pelvic pain)

40-49:

Dermatitis allergic (inflammation of the skin due allergic reaction)
Dizziness
Drug ineffective
Ear infection
Fall
Fungal infection
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hepatic enzyme increased
Immune system disorder
Infusion site pain

50-59:

Haemochromatosis (body to absorb more iron than usual from food)
Hypersensitivity
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Adrenal adenoma (benign tumour of the glandular type (adenoma) in the adrenal gland)
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Angiopathy (generic term for a disease of the blood vessels)
Ankylosing spondylitis (type of arthritis affecting the spine)
Aortic disorder
Arthralgia (joint pain)

60+:

Loss of consciousness
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Renal impairment (severely reduced kidney function)
Sudden onset of sleep
Weight decreased
Abasia (inability to walk)
Renal failure (kidney dysfunction)
Haemoglobin decreased
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 19 people, 23.46%
Back Pain: 16 people, 19.75%
High Blood Pressure: 14 people, 17.28%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 13.58%
High Blood Cholesterol: 11 people, 13.58%
Indigestion: 10 people, 12.35%
Migraine (headache): 8 people, 9.88%
Joint Pain: 8 people, 9.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 8.64%
Neuropathy Peripheral (surface nerve damage): 7 people, 8.64%

* Approximation only. Some reports may have incomplete information.

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