Nucynta and Methocarbamol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nucynta (tapentadol hydrochloride) and Methocarbamol (methocarbamol). Common drug interactions include burning sensation among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Nucynta and Methocarbamol. It is created by eHealthMe based on reports of 87 people who take the same drugs from the FDA, and is updated regularly.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

What is Methocarbamol?

Methocarbamol has active ingredients of methocarbamol. It is often used in muscle spasms. eHealthMe is studying from 17,766 Methocarbamol users. Check the latest studies of Methocarbamol.

On Jul, 07, 2026

87 people who take Nucynta and Methocarbamol together, and have interactions are studied.

Nucynta and Methocarbamol drug interactions.

What are the common drug interactions of Nucynta and Methocarbamol, by gender? *:

female:

Burning sensation
Carbohydrate antigen 125 increased
Cervical spinal stenosis (narrowing of the spinal canal in the neck)
Flatulence (flatus expelled through the anus)
Haematocrit decreased
Haemoglobin decreased
Headache (pain in head)
Hospitalisation
Intervertebral disc degeneration (spinal disc degeneration)
Mean cell haemoglobin increased (more than normal haemoglobin per red blood cell in a sample of blood)

male:

Diarrhoea
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Fatigue (feeling of tiredness)
Gout (uric acid crystals building up in the body)
Neuropathy peripheral (surface nerve damage)
Renal failure (kidney dysfunction)
Slow speech
Activities of daily living impaired
Acute left ventricular failure (heart attack)
Acute myocardial infarction (acute heart attack)

What are the common drug interactions of Nucynta and Methocarbamol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cataract (clouding of the lens inside the eye)
Chronic kidney disease
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Nephrogenic anaemia (anaemia due to kidney disease)
Neuropathy peripheral (surface nerve damage)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Renal failure (kidney dysfunction)

40-49:

Herpes zoster
Insomnia (sleeplessness)
Drug ineffective
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Chronic kidney disease
Adverse event
Ill-defined disorder
Crying
Dehydration (dryness resulting from the removal of water)

50-59:

Psychogenic pain disorder
Social avoidant behaviour (avoiding social connection a personality disorder)
Substance-induced psychotic disorder
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Balance disorder
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Chronic kidney disease
Decreased immune responsiveness
Fatigue (feeling of tiredness)
Gait disturbance

60+:

Diarrhoea
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Sensory disturbance (sense disturbance)
Abdominal pain lower
Alanine aminotransferase increased
Anaemia (lack of blood)
Aspartate aminotransferase increased
Blood alkaline phosphatase increased
Carbohydrate antigen 125 increased
Constipation

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 19 people, 21.84%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 15 people, 17.24%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 10 people, 11.49%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 9 people, 10.34%
High Blood Cholesterol: 8 people, 9.20%
Depression: 8 people, 9.20%
Asthma: 8 people, 9.20%
Migraine (headache): 7 people, 8.05%
Indigestion: 7 people, 8.05%
Neuralgia (pain in one or more nerves): 6 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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