Nucynta and Nitroglycerin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nucynta (tapentadol hydrochloride) and Nitroglycerin (nitroglycerin). Common drug interactions include blood glucose decreased among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Nucynta and Nitroglycerin. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

What is Nitroglycerin?

Nitroglycerin has active ingredients of nitroglycerin. It is often used in chest pain. eHealthMe is studying from 52,884 Nitroglycerin users. Check the latest studies of Nitroglycerin.

On Jul, 11, 2026

55 people who take Nucynta and Nitroglycerin together, and have interactions are studied.

Nucynta and Nitroglycerin drug interactions.

What are the common drug interactions of Nucynta and Nitroglycerin, by gender? *:

female:

Blood glucose decreased
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Epistaxis (bleed from the nose)
Eye haemorrhage (bleeding in the eye)
Injection site bruising
Injection site mass
Injection site pain
Skin haemorrhage (bleeding into skin)
Skin swelling
Blindness

male:

Fall
Muscular weakness (muscle weakness)
Tremor (trembling or shaking movements in one or more parts of your body)
Acute myocardial infarction (acute heart attack)
Cardiac failure congestive
Anxiety
Acute left ventricular failure (heart attack)
Arthropathy
Asthma
Atrioventricular block complete (heart block complete)

What are the common drug interactions of Nucynta and Nitroglycerin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Insomnia (sleeplessness)
Palpitations (feelings or sensations that your heart is pounding or racing)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Tremor (trembling or shaking movements in one or more parts of your body)
Anxiety

30-39:

n/a

40-49:

Arthropathy
Asthma
Bronchitis chronic (inflammation of the mucous membrane in the bronchial tubes- chronic)
Cardiac failure congestive
Chronic kidney disease
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dyslipidaemia (abnormal amount of lipids)
Dyspnoea (difficult or laboured respiration)
Essential hypertension (primary hypertension)

50-59:

Chronic kidney disease
Renal failure (kidney dysfunction)

60+:

Fall
Muscular weakness (muscle weakness)
Urine output decreased
Vomiting
Asthenia (weakness)
Cardiac failure congestive
Cystitis (inflammation of the wall of the bladder)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Abnormal dreams

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 20.00%
Stable Angina (a constant chest pain): 9 people, 16.36%
Asthma: 7 people, 12.73%
High Blood Cholesterol: 7 people, 12.73%
High Blood Pressure: 7 people, 12.73%
Immunodeficiency Common Variable: 7 people, 12.73%
Back Pain: 6 people, 10.91%
Diabetes: 6 people, 10.91%
Prostate Cancer: 6 people, 10.91%
Hypersensitivity: 5 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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