Nucynta and Zocor drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nucynta (tapentadol hydrochloride) and Zocor (simvastatin). Common drug interactions include haematuria among females and serotonin syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Nucynta and Zocor. It is created by eHealthMe based on reports of 71 people who take the same drugs from the FDA, and is updated regularly.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

What is Zocor?

Zocor has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 86,545 Zocor users. Check the latest studies of Zocor.

On Jul, 11, 2026

71 people who take Nucynta and Zocor together, and have interactions are studied.

What are the common drug interactions of Nucynta and Zocor, by gender? *:

female:

Haematuria (presence of blood in urine)
Hospitalisation
Insomnia (sleeplessness)
Pulmonary embolism (blockage of the main artery of the lung)
Urinary tract infection
Abnormal behaviour
Agitation (state of anxiety or nervous excitement)
Bladder neck suspension
Bradycardia (abnormally slow heart action)
Chest pain

male:

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Haemoglobin decreased
Sperm concentration decreased
Confusional state
Overdose
Renal haematoma (blood collection in kidney)
Suicide attempt
Unresponsive to stimuli
Blood glucose increased
Decreased appetite

What are the common drug interactions of Nucynta and Zocor, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Hyperhidrosis (abnormally increased sweating)
Psoriasis (immune-mediated disease that affects the skin)

40-49:

Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Overdose
Suicide attempt
Unresponsive to stimuli
Dizziness
Ear congestion
Hot flush (sudden feelings of heat)
Hyperhidrosis (abnormally increased sweating)
Migraine (headache)
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)

50-59:

Decreased appetite
Depression
Weight decreased
Sinusitis (inflammation of sinus)
Acarodermatitis (skin inflammation caused by mites (acarids))
Agitation (state of anxiety or nervous excitement)
Benign prostatic hyperplasia (benign enlargement of the prostate)
Bladder neck suspension
Bradycardia (abnormally slow heart action)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)

60+:

Loss of consciousness
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)
Sperm concentration decreased
Confusional state
Fall
Contusion (a type of hematoma of tissue in which capillaries)
Cough
Diarrhoea
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 15 people, 21.13%
High Blood Pressure: 15 people, 21.13%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 16.90%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 12 people, 16.90%
Depression: 7 people, 9.86%
Back Pain: 7 people, 9.86%
Stress And Anxiety: 6 people, 8.45%
Multiple Myeloma (cancer of the plasma cells): 5 people, 7.04%
Insomnia (sleeplessness): 5 people, 7.04%
Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 7.04%

* Approximation only. Some reports may have incomplete information.

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