Nuedexta and Sertraline drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nuedexta (dextromethorphan hydrobromide; quinidine sulfate) and Sertraline (sertraline hydrochloride). Common drug interactions include drug effect decreased among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Nuedexta and Sertraline. It is created by eHealthMe based on reports of 76 people who take the same drugs from the FDA, and is updated regularly.

What is Nuedexta?

Nuedexta has active ingredients of dextromethorphan hydrobromide; quinidine sulfate. eHealthMe is studying from 3,781 Nuedexta users. Check the latest studies of Nuedexta.

What is Sertraline?

Sertraline has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 153,305 Sertraline users. Check the latest studies of Sertraline.

On Aug, 11, 2026

76 people who take Nuedexta and Sertraline together, and have interactions are studied.

Nuedexta and Sertraline drug interactions.

What are the common drug interactions of Nuedexta and Sertraline, by gender? *:

female:

Drug effect decreased
Dysphagia (a condition in which swallowing is difficult or painful)
Fall
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Anger
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Gait disturbance
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Fatigue (feeling of tiredness)

male:

Fall
Fatigue (feeling of tiredness)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diarrhoea
Disease recurrence
Gait disturbance
Hallucination, visual (seeing things that aren't there)
Irritability
Mood altered (changes in mood)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

What are the common drug interactions of Nuedexta and Sertraline, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Feeding disorder (when children refuse to eat certain food groups)
Glossodynia (a burning or painful sensation in the tongue)
Tongue haemorrhage (bleeding from tongue)

30-39:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Fall
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Therapeutic response unexpected
Dizziness

40-49:

Visual acuity reduced (reduced clearness of vision)
Drug intolerance (drug sensitivity)
Fall
Visual impairment
Weight decreased
Asthenia (weakness)
Balance disorder
Blood pressure decreased
Liver disorder (liver diseases)
Lymphadenopathy (disease or enlargement of lymph nodes)

50-59:

Fall
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Fatigue (feeling of tiredness)
Visual impairment
Mobility decreased (ability to move is reduced)
Affect lability (emotional incontinence)
Alopecia (absence of hair from areas of the body)
Dizziness
Somnolence (a state of near-sleep, a strong desire for sleep)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

60+:

Anger
Agitation (state of anxiety or nervous excitement)
Restlessness (not able to rest)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Balance disorder
Cardiac disorder
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Dementia (madness)
Fatigue (feeling of tiredness)
Gait disturbance

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 38 people, 50.00%
Parkinson's Disease: 15 people, 19.74%
Stress And Anxiety: 6 people, 7.89%
Migraine (headache): 6 people, 7.89%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 6.58%
Pain: 5 people, 6.58%
Affect Lability (emotional incontinence): 5 people, 6.58%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 5.26%
Fatigue (feeling of tiredness): 4 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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