Nuplazid and Actos drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nuplazid (pimavanserin tartrate) and Actos (pioglitazone hydrochloride). Common drug interactions include fluid imbalance among females and nonspecific reaction among males.

The phase IV clinical study analyzes what interactions people have when they take Nuplazid and Actos. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Nuplazid?

Nuplazid has active ingredients of pimavanserin tartrate. eHealthMe is studying from 47,103 Nuplazid users. Check the latest studies of Nuplazid.

What is Actos?

Actos has active ingredients of pioglitazone hydrochloride. It is often used in diabetes. eHealthMe is studying from 49,754 Actos users. Check the latest studies of Actos.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

29 people who take Nuplazid and Actos together, and have interactions are studied.

What are the common drug interactions of Nuplazid and Actos, by gender? *:

female:

Fluid imbalance (imbalance of fluid in body in intake and fluid lost)
Gait disturbance
Peripheral swelling
Hypersomnia (excessive daytime sleepiness (eds))
Somnolence (a state of near-sleep, a strong desire for sleep)
Fall
Hip fracture
Hospitalisation

male:

Nonspecific reaction (unspecified reaction)
Dizziness postural
Gait disturbance
Hallucination (an experience involving the perception of something not present)
Abnormal behaviour
Leukaemia (blood or bone marrow cancer)
Parkinson's disease
Death
Hip fracture
Restlessness (not able to rest)

What are the common drug interactions of Nuplazid and Actos, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Nonspecific reaction (unspecified reaction)
Dizziness postural
Gait disturbance
Abnormal behaviour
Hallucination (an experience involving the perception of something not present)
Leukaemia (blood or bone marrow cancer)
Parkinson's disease
Death
Restlessness (not able to rest)
Staphylococcal infection (an infection with staphylococcus bacteria)

What are the existing conditions these people have? *

Parkinson's Disease: 21 people, 72.41%
Hallucinations (sensations that appear real but are created by your mind): 10 people, 34.48%
Delusion (a false belief or opinion): 10 people, 34.48%
Pain: 2 people, 6.90%
Constipation: 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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